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GO:0008657: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity (Molecular function)

"Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah]


There are 17 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Sequences (17) (download table)

InterPro Domains

GO Terms

Family Terms