AAC75464 (ligA, b2411)

Aliases : ligA, b2411

Description : DNA ligase, NAD(+)-dependent [Ensembl]. Helix-hairpin-helix motif, Helix-hairpin-helix domain, BRCA1 C Terminus (BRCT) domain, NAD-dependent DNA ligase OB-fold domain, NAD-dependent DNA ligase adenylation domain, NAD-dependent DNA ligase C4 zinc finger domain [Interproscan].

Gene families : OG_02_0000445 (OrthoFinder) Phylogenetic Tree(s): OG0000445_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: AAC75464
Cluster	HCCA: Cluster_29

Target	Alias	Description	ECC score	Gene Family Method	Actions
AAL21321	STM2427, lig	DNA ligase [Ensembl]. Helix-hairpin-helix motif,...	0.03	OrthoFinder

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003909	DNA ligase activity	None	Extended
MF	GO:0003911	DNA ligase (NAD+) activity	IEA	Interproscan
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006260	DNA replication	IEA	Interproscan
BP	GO:0006281	DNA repair	IEA	Interproscan
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006950	response to stress	None	Extended
BP	GO:0006974	cellular response to DNA damage stimulus	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009059	macromolecule biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016874	ligase activity	None	Extended
MF	GO:0016886	ligase activity, forming phosphoric ester bonds	None	Extended
BP	GO:0033554	cellular response to stress	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034645	cellular macromolecule biosynthetic process	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051716	cellular response to stimulus	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0140097	catalytic activity, acting on DNA	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000270	peptidoglycan metabolic process	IEP	Enrichment
MF	GO:0003723	RNA binding	IEP	Enrichment
MF	GO:0003916	DNA topoisomerase activity	IEP	Enrichment
MF	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IEP	Enrichment
MF	GO:0004252	serine-type endopeptidase activity	IEP	Enrichment
MF	GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	IEP	Enrichment
MF	GO:0005507	copper ion binding	IEP	Enrichment
BP	GO:0006022	aminoglycan metabolic process	IEP	Enrichment
BP	GO:0006265	DNA topological change	IEP	Enrichment
BP	GO:0006996	organelle organization	IEP	Enrichment
MF	GO:0008094	ATPase, acting on DNA	IEP	Enrichment
MF	GO:0008168	methyltransferase activity	IEP	Enrichment
BP	GO:0009254	peptidoglycan turnover	IEP	Enrichment
BP	GO:0016043	cellular component organization	IEP	Enrichment
MF	GO:0016741	transferase activity, transferring one-carbon groups	IEP	Enrichment
MF	GO:0016798	hydrolase activity, acting on glycosyl bonds	IEP	Enrichment
MF	GO:0016853	isomerase activity	IEP	Enrichment
BP	GO:0030203	glycosaminoglycan metabolic process	IEP	Enrichment
BP	GO:0032259	methylation	IEP	Enrichment
BP	GO:0051276	chromosome organization	IEP	Enrichment
BP	GO:0071103	DNA conformation change	IEP	Enrichment
BP	GO:0071840	cellular component organization or biogenesis	IEP	Enrichment

InterPro domains	Description	Start	Stop
IPR013839	DNAligase_adenylation	3	318
IPR004149	Znf_DNAligase_C4	407	434
IPR041663	DisA/LigA_HHH	510	573
IPR004150	NAD_DNA_ligase_OB	322	398
IPR001357	BRCT_dom	596	669

External Links

UniProtKB	P15042

AAC75464 (ligA, b2411)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation