AGT23252 (N559_1499, LigA)


Aliases : N559_1499, LigA

Description : NAD-dependent DNA ligase LigA [Ensembl]. NAD-dependent DNA ligase adenylation domain, NAD-dependent DNA ligase OB-fold domain, NAD-dependent DNA ligase C4 zinc finger domain, BRCA1 C Terminus (BRCT) domain, Helix-hairpin-helix domain [InterProScan].


Gene families : OG_02_0000445 (OrthoFinder) Phylogenetic Tree(s): OG0000445_tree

Sequence : coding (download), protein (download)


Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: AGT23252
Cluster HCCA: Cluster_29

Target Alias Description ECC score Gene Family Method Actions
AAK99828 spr1024, ligA DNA ligase [Ensembl]. Helix-hairpin-helix motif,... 0.03 OrthoFinder
ADK87023 ligA, MPNE_0413 DNA ligase (NAD(+)) [Ensembl]. NAD-dependent DNA ligase... 0.04 OrthoFinder
AHY39823 ligA, CJ8421_02860 NAD-dependent DNA ligase LigA [Ensembl].... 0.06 OrthoFinder
AKI49752 ligA, L2625_01894 DNA ligase, NAD-dependent [Ensembl]. NAD-dependent DNA... 0.03 OrthoFinder
AKP15609 ligA_2, WX61_01570 DNA ligase [Ensembl]. Helix-hairpin-helix motif, BRCA1 C... 0.08 OrthoFinder
CPD03240 lig, ERS093114_01872 DNA ligase [Ensembl]. Helix-hairpin-helix motif,... 0.03 OrthoFinder
KNA56407 VCV51_030679 DNA ligase [Ensembl]. Helix-hairpin-helix motif,... 0.04 OrthoFinder

Type GO Term Name Evidence Source
MF GO:0003911 DNA ligase (NAD+) activity IEA Interproscan
BP GO:0006260 DNA replication IEA Interproscan
BP GO:0006281 DNA repair IEA Interproscan
Type GO Term Name Evidence Source
MF GO:0000166 nucleotide binding IEP Enrichment
MF GO:0002161 aminoacyl-tRNA editing activity IEP Enrichment
MF GO:0003676 nucleic acid binding IEP Enrichment
MF GO:0003747 translation release factor activity IEP Enrichment
MF GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEP Enrichment
MF GO:0003916 DNA topoisomerase activity IEP Enrichment
MF GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity IEP Enrichment
MF GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IEP Enrichment
MF GO:0003954 NADH dehydrogenase activity IEP Enrichment
MF GO:0003955 NAD(P)H dehydrogenase (quinone) activity IEP Enrichment
MF GO:0004107 chorismate synthase activity IEP Enrichment
MF GO:0004812 aminoacyl-tRNA ligase activity IEP Enrichment
MF GO:0004813 alanine-tRNA ligase activity IEP Enrichment
MF GO:0004814 arginine-tRNA ligase activity IEP Enrichment
MF GO:0005096 GTPase activator activity IEP Enrichment
MF GO:0005488 binding IEP Enrichment
MF GO:0005524 ATP binding IEP Enrichment
MF GO:0005525 GTP binding IEP Enrichment
CC GO:0005694 chromosome IEP Enrichment
BP GO:0006081 cellular aldehyde metabolic process IEP Enrichment
BP GO:0006082 organic acid metabolic process IEP Enrichment
BP GO:0006265 DNA topological change IEP Enrichment
BP GO:0006323 DNA packaging IEP Enrichment
BP GO:0006396 RNA processing IEP Enrichment
BP GO:0006399 tRNA metabolic process IEP Enrichment
BP GO:0006415 translational termination IEP Enrichment
BP GO:0006418 tRNA aminoacylation for protein translation IEP Enrichment
BP GO:0006419 alanyl-tRNA aminoacylation IEP Enrichment
BP GO:0006420 arginyl-tRNA aminoacylation IEP Enrichment
BP GO:0006520 cellular amino acid metabolic process IEP Enrichment
BP GO:0006612 protein targeting to membrane IEP Enrichment
BP GO:0006613 cotranslational protein targeting to membrane IEP Enrichment
BP GO:0006614 SRP-dependent cotranslational protein targeting to membrane IEP Enrichment
BP GO:0006996 organelle organization IEP Enrichment
BP GO:0007059 chromosome segregation IEP Enrichment
MF GO:0008047 enzyme activator activity IEP Enrichment
MF GO:0008079 translation termination factor activity IEP Enrichment
MF GO:0008094 ATPase, acting on DNA IEP Enrichment
BP GO:0008104 protein localization IEP Enrichment
MF GO:0008137 NADH dehydrogenase (ubiquinone) activity IEP Enrichment
MF GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity IEP Enrichment
BP GO:0009240 isopentenyl diphosphate biosynthetic process IEP Enrichment
CC GO:0009295 nucleoid IEP Enrichment
BP GO:0015031 protein transport IEP Enrichment
BP GO:0016043 cellular component organization IEP Enrichment
BP GO:0016070 RNA metabolic process IEP Enrichment
MF GO:0016651 oxidoreductase activity, acting on NAD(P)H IEP Enrichment
MF GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IEP Enrichment
MF GO:0016726 oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor IEP Enrichment
MF GO:0016744 transketolase or transaldolase activity IEP Enrichment
MF GO:0016787 hydrolase activity IEP Enrichment
MF GO:0016838 carbon-oxygen lyase activity, acting on phosphates IEP Enrichment
MF GO:0016853 isomerase activity IEP Enrichment
MF GO:0016859 cis-trans isomerase activity IEP Enrichment
MF GO:0016866 intramolecular transferase activity IEP Enrichment
MF GO:0016868 intramolecular transferase activity, phosphotransferases IEP Enrichment
MF GO:0016875 ligase activity, forming carbon-oxygen bonds IEP Enrichment
BP GO:0017038 protein import IEP Enrichment
MF GO:0017076 purine nucleotide binding IEP Enrichment
MF GO:0019001 guanyl nucleotide binding IEP Enrichment
BP GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway IEP Enrichment
BP GO:0019682 glyceraldehyde-3-phosphate metabolic process IEP Enrichment
BP GO:0019752 carboxylic acid metabolic process IEP Enrichment
BP GO:0022411 cellular component disassembly IEP Enrichment
BP GO:0030261 chromosome condensation IEP Enrichment
MF GO:0030554 adenyl nucleotide binding IEP Enrichment
MF GO:0030695 GTPase regulator activity IEP Enrichment
MF GO:0032553 ribonucleotide binding IEP Enrichment
MF GO:0032555 purine ribonucleotide binding IEP Enrichment
MF GO:0032559 adenyl ribonucleotide binding IEP Enrichment
MF GO:0032561 guanyl ribonucleotide binding IEP Enrichment
BP GO:0032984 protein-containing complex disassembly IEP Enrichment
BP GO:0033036 macromolecule localization IEP Enrichment
BP GO:0033365 protein localization to organelle IEP Enrichment
BP GO:0034470 ncRNA processing IEP Enrichment
BP GO:0034613 cellular protein localization IEP Enrichment
BP GO:0034660 ncRNA metabolic process IEP Enrichment
MF GO:0035596 methylthiotransferase activity IEP Enrichment
MF GO:0035639 purine ribonucleoside triphosphate binding IEP Enrichment
MF GO:0036094 small molecule binding IEP Enrichment
BP GO:0043038 amino acid activation IEP Enrichment
BP GO:0043039 tRNA aminoacylation IEP Enrichment
MF GO:0043167 ion binding IEP Enrichment
MF GO:0043168 anion binding IEP Enrichment
BP GO:0043436 oxoacid metabolic process IEP Enrichment
BP GO:0043624 cellular protein complex disassembly IEP Enrichment
BP GO:0043933 protein-containing complex subunit organization IEP Enrichment
BP GO:0044281 small molecule metabolic process IEP Enrichment
BP GO:0045047 protein targeting to ER IEP Enrichment
BP GO:0045184 establishment of protein localization IEP Enrichment
CC GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) IEP Enrichment
MF GO:0045301 tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity IEP Enrichment
BP GO:0046034 ATP metabolic process IEP Enrichment
BP GO:0046490 isopentenyl diphosphate metabolic process IEP Enrichment
MF GO:0048038 quinone binding IEP Enrichment
MF GO:0050136 NADH dehydrogenase (quinone) activity IEP Enrichment
MF GO:0050497 alkylthioltransferase activity IEP Enrichment
BP GO:0050992 dimethylallyl diphosphate biosynthetic process IEP Enrichment
BP GO:0050993 dimethylallyl diphosphate metabolic process IEP Enrichment
BP GO:0051276 chromosome organization IEP Enrichment
MF GO:0051539 4 iron, 4 sulfur cluster binding IEP Enrichment
BP GO:0051668 localization within membrane IEP Enrichment
MF GO:0051745 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity IEP Enrichment
MF GO:0052689 carboxylic ester hydrolase activity IEP Enrichment
MF GO:0060589 nucleoside-triphosphatase regulator activity IEP Enrichment
BP GO:0070727 cellular macromolecule localization IEP Enrichment
BP GO:0070972 protein localization to endoplasmic reticulum IEP Enrichment
BP GO:0071103 DNA conformation change IEP Enrichment
BP GO:0071840 cellular component organization or biogenesis IEP Enrichment
BP GO:0072594 establishment of protein localization to organelle IEP Enrichment
BP GO:0072599 establishment of protein localization to endoplasmic reticulum IEP Enrichment
BP GO:0072657 protein localization to membrane IEP Enrichment
BP GO:0090150 establishment of protein localization to membrane IEP Enrichment
MF GO:0097159 organic cyclic compound binding IEP Enrichment
MF GO:0097367 carbohydrate derivative binding IEP Enrichment
MF GO:0140096 catalytic activity, acting on a protein IEP Enrichment
MF GO:0140098 catalytic activity, acting on RNA IEP Enrichment
MF GO:0140101 catalytic activity, acting on a tRNA IEP Enrichment
MF GO:1901265 nucleoside phosphate binding IEP Enrichment
MF GO:1901363 heterocyclic compound binding IEP Enrichment
BP GO:1901564 organonitrogen compound metabolic process IEP Enrichment
BP GO:1902600 proton transmembrane transport IEP Enrichment
InterPro domains Description Start Stop
IPR013839 DNAligase_adenylation 2 294
IPR004150 NAD_DNA_ligase_OB 298 374
IPR041663 DisA/LigA_HHH 486 549
IPR004149 Znf_DNAligase_C4 383 410
IPR001357 BRCT_dom 572 644
No external refs found!