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AAC73185 (leuA, b0074)


Aliases : leuA, b0074

Description : 2-isopropylmalate synthase [Ensembl]. HMGL-like, LeuA allosteric (dimerisation) domain [Interproscan].


Gene families : OG_02_0000655 (OrthoFinder) Phylogenetic Tree(s): OG0000655_tree

Sequence : coding (download), protein (download)


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Type Description Actions
Neighborhood HRR: AAC73185
Cluster HCCA: Cluster_2

Target Alias Description ECC score Gene Family Method Actions
AAK99939 spr1136 2-isopropylmalate synthase, truncation [Ensembl]. LeuA... 0.04 OrthoFinder
AAL19077 STM0113, leuA 2-isopropylmalate synthase [Ensembl]. HMGL-like, LeuA... 0.08 OrthoFinder
AGT25961 N559_4351 2-isopropylmalate synthase [Ensembl]. LeuA allosteric... 0.05 OrthoFinder
AHY40904 CJ8421_08660 2-isopropylmalate synthase [Ensembl]. HMGL-like, LeuA... 0.04 OrthoFinder
AKI49982 leuA, L2625_02135 2-isopropylmalate synthase [Ensembl]. Pyruvate... 0.04 OrthoFinder
CPD08084 leuA_2, ERS093114_02010 2-isopropylmalate synthase [Ensembl]. HMGL-like, LeuA... 0.09 OrthoFinder
EDJ91783 CGSHi22421_08508 2-isopropylmalate synthase [Ensembl]. HMGL-like [Interproscan]. 0.04 OrthoFinder
KNA51159 VCV51_031676 2-isopropylmalate synthase [Ensembl]. HMGL-like, LeuA... 0.04 OrthoFinder

Type GO Term Name Evidence Source
MF GO:0003824 catalytic activity IEA Interproscan
MF GO:0003852 2-isopropylmalate synthase activity IEA Interproscan
BP GO:0009098 leucine biosynthetic process IEA Interproscan
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Type GO Term Name Evidence Source
MF GO:0000287 magnesium ion binding IEP Enrichment
MF GO:0004345 glucose-6-phosphate dehydrogenase activity IEP Enrichment
MF GO:0004455 ketol-acid reductoisomerase activity IEP Enrichment
MF GO:0004474 malate synthase activity IEP Enrichment
BP GO:0006006 glucose metabolic process IEP Enrichment
BP GO:0006081 cellular aldehyde metabolic process IEP Enrichment
BP GO:0006097 glyoxylate cycle IEP Enrichment
BP GO:0006772 thiamine metabolic process IEP Enrichment
MF GO:0008641 ubiquitin-like modifier activating enzyme activity IEP Enrichment
BP GO:0009081 branched-chain amino acid metabolic process IEP Enrichment
BP GO:0009082 branched-chain amino acid biosynthetic process IEP Enrichment
BP GO:0009228 thiamine biosynthetic process IEP Enrichment
MF GO:0015035 protein-disulfide reductase activity IEP Enrichment
MF GO:0015036 disulfide oxidoreductase activity IEP Enrichment
MF GO:0016491 oxidoreductase activity IEP Enrichment
MF GO:0016614 oxidoreductase activity, acting on CH-OH group of donors IEP Enrichment
MF GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEP Enrichment
MF GO:0016667 oxidoreductase activity, acting on a sulfur group of donors IEP Enrichment
MF GO:0016877 ligase activity, forming carbon-sulfur bonds IEP Enrichment
MF GO:0019842 vitamin binding IEP Enrichment
MF GO:0030976 thiamine pyrophosphate binding IEP Enrichment
BP GO:0042723 thiamine-containing compound metabolic process IEP Enrichment
BP GO:0042724 thiamine-containing compound biosynthetic process IEP Enrichment
BP GO:0044272 sulfur compound biosynthetic process IEP Enrichment
BP GO:0046487 glyoxylate metabolic process IEP Enrichment
MF GO:0050661 NADP binding IEP Enrichment
BP GO:0055114 obsolete oxidation-reduction process IEP Enrichment
BP GO:0072527 pyrimidine-containing compound metabolic process IEP Enrichment
BP GO:0072528 pyrimidine-containing compound biosynthetic process IEP Enrichment
MF GO:1901681 sulfur compound binding IEP Enrichment
InterPro domains Description Start Stop
IPR013709 2-isopropylmalate_synth_dimer 369 499
IPR000891 PYR_CT 4 273
UniProtKB P09151