AAC74356 (topA, b1274)

Aliases : topA, b1274

Description : DNA topoisomerase I, omega subunit [Ensembl]. Toprim domain, DNA topoisomerase, Topoisomerase I zinc-ribbon-like, Topoisomerase DNA binding C4 zinc finger [Interproscan].

Gene families : OG_02_0000393 (OrthoFinder) Phylogenetic Tree(s): OG0000393_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: AAC74356
Cluster	HCCA: Cluster_21

Target	Alias	Description	ECC score	Gene Family Method	Actions
AAK99944	spr1141, topA	DNA topoisomerase I [Ensembl]. Toprim domain, DNA...	0.02	OrthoFinder
AHY40871	CJ8421_08495	DNA topoisomerase I [Ensembl]. Toprim domain, DNA...	0.01	OrthoFinder

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	IEA	Interproscan
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003916	DNA topoisomerase activity	IEA	Interproscan
MF	GO:0003917	DNA topoisomerase type I (single strand cut, ATP-independent) activity	IEA	Interproscan
MF	GO:0005488	binding	None	Extended
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005694	chromosome	IEA	Interproscan
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006265	DNA topological change	IEA	Interproscan
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006996	organelle organization	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016043	cellular component organization	None	Extended
MF	GO:0016853	isomerase activity	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043228	non-membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043232	intracellular non-membrane-bounded organelle	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0051276	chromosome organization	None	Extended
BP	GO:0071103	DNA conformation change	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0071840	cellular component organization or biogenesis	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
CC	GO:0110165	cellular anatomical entity	None	Extended
MF	GO:0140097	catalytic activity, acting on DNA	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0016887	ATPase	IEP	Enrichment

InterPro domains	Description	Start	Stop
IPR006171	TOPRIM_domain	5	142
IPR013498	Topo_IA_Znf	597	622
IPR013498	Topo_IA_Znf	709	745
IPR013497	Topo_IA_cen	157	565
IPR013263	TopoI_Znr_bac	824	862
IPR013263	TopoI_Znr_bac	758	793

External Links

UniProtKB	P06612

AAC74356 (topA, b1274)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation