GO:0140358: P-type transmembrane transporter activity (Molecular function)

"Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol." [PMID:18075584, PMID:25918123]

There are 289 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_1 Escherichia coli 1.87 % 0.000662 0.002019
Cluster_37 Pseudomonas aeruginosa 3.12 % 0.000283 0.009567
Cluster_12 Salmonella enterica 1.87 % 0.000547 0.020396
Cluster_12 Staphylococcus aureus 2.08 % 0.001311 0.008663
Sequences (289) (download table)

InterPro Domains

GO Terms

Family Terms