AAC75087 (hisI, b2026)

Aliases : hisI, b2026

Description : phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphatase [Ensembl]. Phosphoribosyl-AMP cyclohydrolase, Phosphoribosyl-ATP pyrophosphohydrolase [Interproscan].

Gene families : OG_02_0000827 (OrthoFinder) Phylogenetic Tree(s): OG0000827_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: AAC75087
Cluster	HCCA: Cluster_32

Target	Alias	Description	ECC score	Gene Family Method
AAL20982	STM2078, hisI	phosphoribosyl-AMP cyclohydrolase [Ensembl]....	0.16	OrthoFinder
AGT23511	N559_1775	bifunctional phosphoribosyl-AMP...	0.09	OrthoFinder
AHY40777	CJ8421_08025	bifunctional phosphoribosyl-AMP...	0.04	OrthoFinder
AKI48511	hisI, L2625_00575	phosphoribosyl-AMP cyclohydrolase [Ensembl]....	0.06	OrthoFinder
CCL17756	hisI, BN171_1760001	Histidine biosynthesis bifunctional protein HisIE...	0.09	OrthoFinder
CCP44370	hisI, Rv1606	Probable phosphoribosyl-AMP 1,6 cyclohydrolase HisI...	0.07	OrthoFinder
CPC67916	hisI, ERS093114_01038	Phosphoribosyl-AMP cyclohydrolase / Phosphoribosyl-ATP...	0.25	OrthoFinder
EDJ91517	atpC, CGSHi22421_07097	F0F1 ATP synthase subunit epsilon [Ensembl]....	0.12	OrthoFinder
KNA53867	VCV51_030805	phosphoribosyl-ATP pyrophosphohydrolase [Ensembl]....	0.12	OrthoFinder

Type	GO Term	Name	Evidence	Source
BP	GO:0000105	histidine biosynthetic process	IEA	Interproscan
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004635	phosphoribosyl-AMP cyclohydrolase activity	IEA	Interproscan
BP	GO:0006082	organic acid metabolic process	None	Extended
BP	GO:0006520	cellular amino acid metabolic process	None	Extended
BP	GO:0006547	histidine metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0008652	cellular amino acid biosynthetic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016053	organic acid biosynthetic process	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	None	Extended
MF	GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	None	Extended
MF	GO:0019238	cyclohydrolase activity	None	Extended
BP	GO:0019752	carboxylic acid metabolic process	None	Extended
BP	GO:0043436	oxoacid metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0044283	small molecule biosynthetic process	None	Extended
BP	GO:0046394	carboxylic acid biosynthetic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901566	organonitrogen compound biosynthetic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000287	magnesium ion binding	IEP	Enrichment
MF	GO:0003879	ATP phosphoribosyltransferase activity	IEP	Enrichment
MF	GO:0004399	histidinol dehydrogenase activity	IEP	Enrichment
MF	GO:0004424	imidazoleglycerol-phosphate dehydratase activity	IEP	Enrichment
BP	GO:0006553	lysine metabolic process	IEP	Enrichment
MF	GO:0008839	4-hydroxy-tetrahydrodipicolinate reductase	IEP	Enrichment
BP	GO:0009066	aspartate family amino acid metabolic process	IEP	Enrichment
BP	GO:0009067	aspartate family amino acid biosynthetic process	IEP	Enrichment
BP	GO:0009085	lysine biosynthetic process	IEP	Enrichment
BP	GO:0009089	lysine biosynthetic process via diaminopimelate	IEP	Enrichment
MF	GO:0016491	oxidoreductase activity	IEP	Enrichment
MF	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEP	Enrichment
MF	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	IEP	Enrichment
MF	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	IEP	Enrichment
MF	GO:0016763	pentosyltransferase activity	IEP	Enrichment
MF	GO:0016835	carbon-oxygen lyase activity	IEP	Enrichment
MF	GO:0016836	hydro-lyase activity	IEP	Enrichment
MF	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	IEP	Enrichment
MF	GO:0043167	ion binding	IEP	Enrichment
MF	GO:0043169	cation binding	IEP	Enrichment
BP	GO:0043648	dicarboxylic acid metabolic process	IEP	Enrichment
BP	GO:0046451	diaminopimelate metabolic process	IEP	Enrichment
MF	GO:0046872	metal ion binding	IEP	Enrichment
MF	GO:0046983	protein dimerization activity	IEP	Enrichment
MF	GO:0051287	NAD binding	IEP	Enrichment
BP	GO:0055114	obsolete oxidation-reduction process	IEP	Enrichment
BP	GO:1901607	alpha-amino acid biosynthetic process	IEP	Enrichment

InterPro domains	Description	Start	Stop
IPR021130	PRib-ATP_PPHydrolase-like	116	202
IPR002496	PRib_AMP_CycHydrolase_dom	33	105

External Links

UniProtKB	P06989

AAC75087 (hisI, b2026)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation