CCP46497 (nth, Rv3674c)

Aliases : nth, Rv3674c

Description : Probable endonuclease III Nth (DNA-(apurinic or apyrimidinic site)lyase) (AP lyase) (AP endonuclease class I) (endodeoxyribonuclease (apurinic or apyrimidinic)) (deoxyribonuclease (apurinic or apyrimidinic)) [Ensembl]. Helix-hairpin-helix motif, Iron-sulfur binding domain of endonuclease III, HhH-GPD superfamily base excision DNA repair protein [Interproscan].

Gene families : OG_02_0000527 (OrthoFinder) Phylogenetic Tree(s): OG0000527_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: CCP46497
Cluster	HCCA: Cluster_18

Target	Alias	Description	ECC score	Gene Family Method	Actions
AAC74705	nth, b1633	DNA glycosylase and apyrimidinic (AP) lyase...	0.02	OrthoFinder
CCG26728	No alias	Endonuclease III [Ensembl]. Helix-hairpin-helix motif,...	0.03	OrthoFinder

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	IEA	Interproscan
MF	GO:0005488	binding	None	Extended
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006281	DNA repair	None	Extended
BP	GO:0006284	base-excision repair	IEA	Interproscan
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006950	response to stress	None	Extended
BP	GO:0006974	cellular response to DNA damage stimulus	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0033554	cellular response to stress	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
MF	GO:0051536	iron-sulfur cluster binding	None	Extended
MF	GO:0051539	4 iron, 4 sulfur cluster binding	IEA	Interproscan
MF	GO:0051540	metal cluster binding	None	Extended
BP	GO:0051716	cellular response to stimulus	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000271	polysaccharide biosynthetic process	IEP	Enrichment
BP	GO:0000413	protein peptidyl-prolyl isomerization	IEP	Enrichment
MF	GO:0003723	RNA binding	IEP	Enrichment
MF	GO:0003747	translation release factor activity	IEP	Enrichment
MF	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	IEP	Enrichment
MF	GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity	IEP	Enrichment
BP	GO:0005976	polysaccharide metabolic process	IEP	Enrichment
BP	GO:0006082	organic acid metabolic process	IEP	Enrichment
BP	GO:0006415	translational termination	IEP	Enrichment
BP	GO:0006520	cellular amino acid metabolic process	IEP	Enrichment
BP	GO:0006528	asparagine metabolic process	IEP	Enrichment
BP	GO:0006529	asparagine biosynthetic process	IEP	Enrichment
MF	GO:0008079	translation termination factor activity	IEP	Enrichment
MF	GO:0008135	translation factor activity, RNA binding	IEP	Enrichment
MF	GO:0008767	UDP-galactopyranose mutase activity	IEP	Enrichment
MF	GO:0016597	amino acid binding	IEP	Enrichment
MF	GO:0016743	carboxyl- or carbamoyltransferase activity	IEP	Enrichment
MF	GO:0016853	isomerase activity	IEP	Enrichment
MF	GO:0016859	cis-trans isomerase activity	IEP	Enrichment
MF	GO:0016874	ligase activity	IEP	Enrichment
MF	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	IEP	Enrichment
BP	GO:0018193	peptidyl-amino acid modification	IEP	Enrichment
BP	GO:0018208	peptidyl-proline modification	IEP	Enrichment
BP	GO:0019752	carboxylic acid metabolic process	IEP	Enrichment
MF	GO:0019843	rRNA binding	IEP	Enrichment
BP	GO:0022411	cellular component disassembly	IEP	Enrichment
BP	GO:0032984	protein-containing complex disassembly	IEP	Enrichment
MF	GO:0035596	methylthiotransferase activity	IEP	Enrichment
BP	GO:0043436	oxoacid metabolic process	IEP	Enrichment
BP	GO:0043624	cellular protein complex disassembly	IEP	Enrichment
MF	GO:0045182	translation regulator activity	IEP	Enrichment
MF	GO:0050497	alkylthioltransferase activity	IEP	Enrichment
MF	GO:0090079	translation regulator activity, nucleic acid binding	IEP	Enrichment
BP	GO:1901564	organonitrogen compound metabolic process	IEP	Enrichment

InterPro domains	Description	Start	Stop
IPR000445	HhH_motif	91	118
IPR003651	Endonuclease3_FeS-loop_motif	179	195
IPR003265	HhH-GPD_domain	26	160

External Links

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CCP46497 (nth, Rv3674c)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation