AAC75273 (ada, b2213)

Aliases : ada, b2213

Description : fused DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase [Ensembl]. Helix-turn-helix domain, Metal binding domain of Ada, 6-O-methylguanine DNA methyltransferase [Interproscan].

Gene families : OG_02_0000175 (OrthoFinder) Phylogenetic Tree(s): OG0000175_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: AAC75273
Cluster	HCCA: Cluster_28

Target	Alias	Description	ECC score	Gene Family Method	Actions
CRO11876	ada_2	Regulatory protein of adaptative response [Ensembl]....	0.03	OrthoFinder

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	IEA	Interproscan
MF	GO:0003700	DNA-binding transcription factor activity	IEA	Interproscan
MF	GO:0003824	catalytic activity	IEA	Interproscan
MF	GO:0003908	methylated-DNA-[protein]-cysteine S-methyltransferase activity	IEA	Interproscan
MF	GO:0005488	binding	None	Extended
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006281	DNA repair	IEA	Interproscan
BP	GO:0006355	regulation of transcription, DNA-templated	IEA	Interproscan
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006950	response to stress	None	Extended
BP	GO:0006974	cellular response to DNA damage stimulus	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008168	methyltransferase activity	IEA	Interproscan
MF	GO:0008172	S-methyltransferase activity	None	Extended
MF	GO:0008270	zinc ion binding	IEA	Interproscan
BP	GO:0009889	regulation of biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0010468	regulation of gene expression	None	Extended
BP	GO:0010556	regulation of macromolecule biosynthetic process	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016741	transferase activity, transferring one-carbon groups	None	Extended
BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	None	Extended
BP	GO:0019222	regulation of metabolic process	None	Extended
BP	GO:0031323	regulation of cellular metabolic process	None	Extended
BP	GO:0031326	regulation of cellular biosynthetic process	None	Extended
BP	GO:0033554	cellular response to stress	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043169	cation binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
MF	GO:0043565	sequence-specific DNA binding	IEA	Interproscan
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
MF	GO:0046872	metal ion binding	None	Extended
MF	GO:0046914	transition metal ion binding	None	Extended
BP	GO:0050789	regulation of biological process	None	Extended
BP	GO:0050794	regulation of cellular process	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051171	regulation of nitrogen compound metabolic process	None	Extended
BP	GO:0051252	regulation of RNA metabolic process	None	Extended
BP	GO:0051716	cellular response to stimulus	None	Extended
BP	GO:0060255	regulation of macromolecule metabolic process	None	Extended
BP	GO:0065007	biological regulation	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0080090	regulation of primary metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0140110	transcription regulator activity	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1903506	regulation of nucleic acid-templated transcription	None	Extended
BP	GO:2000112	regulation of cellular macromolecule biosynthetic process	None	Extended
BP	GO:2001141	regulation of RNA biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0003697	single-stranded DNA binding	IEP	Enrichment
MF	GO:0004180	carboxypeptidase activity	IEP	Enrichment
MF	GO:0004181	metallocarboxypeptidase activity	IEP	Enrichment
MF	GO:0004857	enzyme inhibitor activity	IEP	Enrichment
MF	GO:0004866	endopeptidase inhibitor activity	IEP	Enrichment
CC	GO:0005615	extracellular space	IEP	Enrichment
MF	GO:0008081	phosphoric diester hydrolase activity	IEP	Enrichment
MF	GO:0008235	metalloexopeptidase activity	IEP	Enrichment
MF	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	IEP	Enrichment
MF	GO:0016787	hydrolase activity	IEP	Enrichment
BP	GO:0018142	protein-DNA covalent cross-linking	IEP	Enrichment
BP	GO:0018143	nucleic acid-protein covalent cross-linking	IEP	Enrichment
MF	GO:0030414	peptidase inhibitor activity	IEP	Enrichment
MF	GO:0061134	peptidase regulator activity	IEP	Enrichment
MF	GO:0061135	endopeptidase regulator activity	IEP	Enrichment

InterPro domains	Description	Start	Stop
IPR018060	HTH_AraC	105	181
IPR014048	MethylDNA_cys_MeTrfase_DNA-bd	270	348
IPR004026	Ada_DNA_repair_Zn-bd	11	75
IPR008332	MethylG_MeTrfase_N	189	266

External Links

UniProtKB	P06134

AAC75273 (ada, b2213)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation