GO:0000155: phosphorelay sensor kinase activity (Molecular function)

"Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038]

There are 1457 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_32 Clostridioides difficile 7.94 % 0.000213 0.004385
Cluster_8 Mycoplasma pneumoniae 33.33 % 0.004769 0.023251
Cluster_15 Pseudomonas aeruginosa 3.92 % 0.008638 0.040974
Cluster_49 Pseudomonas aeruginosa 8.33 % 2e-05 0.000856
Cluster_67 Salmonella enterica 33.33 % 0.01312 0.045921
Cluster_7 Salmonella enterica 3.7 % 0.001081 0.017687
Sequences (1457) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro Domains

Family Terms