AAC76861 (polA, b3863)

Aliases : polA, b3863

Description : 5' to 3' DNA polymerase and 3' to 5'/5' to 3' exonuclease [Ensembl]. 5'-3' exonuclease, 3'-5' exonuclease, DNA polymerase family A [Interproscan].

Gene families : OG_02_0000357 (OrthoFinder) Phylogenetic Tree(s): OG0000357_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: AAC76861
Cluster	HCCA: Cluster_39

Target	Alias	Description	ECC score	Gene Family Method
AAL22838	STM3999, polA	DNA polymerase I [Ensembl]. 5'-3' exonuclease, 3'-5'...	0.15	OrthoFinder
AHY39592	CJ8421_01675	DNA polymerase I [Ensembl]. 5'-3' exonuclease, 3'-5'...	0.03	OrthoFinder
KNA53604	VCV51_030076	DNA polymerase I [Ensembl]. 5'-3' exonuclease, 3'-5'...	0.03	OrthoFinder

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	IEA	Interproscan
MF	GO:0003677	DNA binding	IEA	Interproscan
MF	GO:0003824	catalytic activity	IEA	Interproscan
MF	GO:0003887	DNA-directed DNA polymerase activity	IEA	Interproscan
MF	GO:0004518	nuclease activity	None	Extended
MF	GO:0004527	exonuclease activity	None	Extended
MF	GO:0005488	binding	None	Extended
BP	GO:0006139	nucleobase-containing compound metabolic process	IEA	Interproscan
BP	GO:0006260	DNA replication	IEA	Interproscan
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008408	3'-5' exonuclease activity	IEA	Interproscan
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009059	macromolecule biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	None	Extended
MF	GO:0016779	nucleotidyltransferase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016788	hydrolase activity, acting on ester bonds	None	Extended
MF	GO:0034061	DNA polymerase activity	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034645	cellular macromolecule biosynthetic process	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0140097	catalytic activity, acting on DNA	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000154	rRNA modification	IEP	Enrichment
MF	GO:0000166	nucleotide binding	IEP	Enrichment
BP	GO:0001510	RNA methylation	IEP	Enrichment
BP	GO:0001514	selenocysteine incorporation	IEP	Enrichment
MF	GO:0004347	glucose-6-phosphate isomerase activity	IEP	Enrichment
MF	GO:0004363	glutathione synthase activity	IEP	Enrichment
MF	GO:0004418	hydroxymethylbilane synthase activity	IEP	Enrichment
MF	GO:0004476	mannose-6-phosphate isomerase activity	IEP	Enrichment
MF	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	IEP	Enrichment
MF	GO:0004852	uroporphyrinogen-III synthase activity	IEP	Enrichment
MF	GO:0004853	uroporphyrinogen decarboxylase activity	IEP	Enrichment
BP	GO:0006451	translational readthrough	IEP	Enrichment
BP	GO:0006553	lysine metabolic process	IEP	Enrichment
BP	GO:0006749	glutathione metabolic process	IEP	Enrichment
BP	GO:0006750	glutathione biosynthetic process	IEP	Enrichment
BP	GO:0006796	phosphate-containing compound metabolic process	IEP	Enrichment
MF	GO:0008080	N-acetyltransferase activity	IEP	Enrichment
MF	GO:0008237	metallopeptidase activity	IEP	Enrichment
MF	GO:0008817	cob(I)yrinic acid a,c-diamide adenosyltransferase activity	IEP	Enrichment
MF	GO:0008837	diaminopimelate epimerase activity	IEP	Enrichment
BP	GO:0009085	lysine biosynthetic process	IEP	Enrichment
BP	GO:0009089	lysine biosynthetic process via diaminopimelate	IEP	Enrichment
BP	GO:0009435	NAD biosynthetic process	IEP	Enrichment
MF	GO:0016407	acetyltransferase activity	IEP	Enrichment
MF	GO:0016410	N-acyltransferase activity	IEP	Enrichment
MF	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	IEP	Enrichment
MF	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	IEP	Enrichment
MF	GO:0016831	carboxy-lyase activity	IEP	Enrichment
MF	GO:0016853	isomerase activity	IEP	Enrichment
MF	GO:0016860	intramolecular oxidoreductase activity	IEP	Enrichment
MF	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	IEP	Enrichment
MF	GO:0017076	purine nucleotide binding	IEP	Enrichment
BP	GO:0018130	heterocycle biosynthetic process	IEP	Enrichment
BP	GO:0019184	nonribosomal peptide biosynthetic process	IEP	Enrichment
BP	GO:0019438	aromatic compound biosynthetic process	IEP	Enrichment
MF	GO:0030551	cyclic nucleotide binding	IEP	Enrichment
BP	GO:0031167	rRNA methylation	IEP	Enrichment
BP	GO:0032324	molybdopterin cofactor biosynthetic process	IEP	Enrichment
MF	GO:0032553	ribonucleotide binding	IEP	Enrichment
MF	GO:0032555	purine ribonucleotide binding	IEP	Enrichment
BP	GO:0033013	tetrapyrrole metabolic process	IEP	Enrichment
BP	GO:0033014	tetrapyrrole biosynthetic process	IEP	Enrichment
MF	GO:0035438	cyclic-di-GMP binding	IEP	Enrichment
MF	GO:0036094	small molecule binding	IEP	Enrichment
MF	GO:0043167	ion binding	IEP	Enrichment
MF	GO:0043168	anion binding	IEP	Enrichment
BP	GO:0044271	cellular nitrogen compound biosynthetic process	IEP	Enrichment
BP	GO:0046451	diaminopimelate metabolic process	IEP	Enrichment
MF	GO:0047661	amino-acid racemase activity	IEP	Enrichment
MF	GO:0051499	D-aminoacyl-tRNA deacylase activity	IEP	Enrichment
BP	GO:0070475	rRNA base methylation	IEP	Enrichment
MF	GO:1901265	nucleoside phosphate binding	IEP	Enrichment
BP	GO:1901362	organic cyclic compound biosynthetic process	IEP	Enrichment
BP	GO:1901564	organonitrogen compound metabolic process	IEP	Enrichment
BP	GO:1901566	organonitrogen compound biosynthetic process	IEP	Enrichment

InterPro domains	Description	Start	Stop
IPR001098	DNA-dir_DNA_pol_A_palm_dom	552	925
IPR020045	DNA_polI_H3TH	171	271
IPR020046	5-3_exonucl_a-hlix_arch_N	9	170
IPR002562	3'-5'_exonuclease_dom	330	516

External Links

UniProtKB	P00582

AAC76861 (polA, b3863)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation