EDJ91896 (ligA, CGSHi22421_09073)

Aliases : ligA, CGSHi22421_09073

Description : NAD-dependent DNA ligase LigA [Ensembl]. Helix-hairpin-helix motif, Helix-hairpin-helix domain, BRCA1 C Terminus (BRCT) domain, NAD-dependent DNA ligase OB-fold domain, NAD-dependent DNA ligase adenylation domain, NAD-dependent DNA ligase C4 zinc finger domain [Interproscan].

Gene families : OG_02_0000445 (OrthoFinder) Phylogenetic Tree(s): OG0000445_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: EDJ91896
Cluster	HCCA: Cluster_11

Target	Alias	Description	ECC score	Gene Family Method
AAL21321	STM2427, lig	DNA ligase [Ensembl]. Helix-hairpin-helix motif,...	0.04	OrthoFinder
AKI49752	ligA, L2625_01894	DNA ligase, NAD-dependent [Ensembl]. NAD-dependent DNA...	0.03	OrthoFinder
AKP15609	ligA_2, WX61_01570	DNA ligase [Ensembl]. Helix-hairpin-helix motif, BRCA1 C...	0.04	OrthoFinder
KNA56407	VCV51_030679	DNA ligase [Ensembl]. Helix-hairpin-helix motif,...	0.07	OrthoFinder

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003909	DNA ligase activity	None	Extended
MF	GO:0003911	DNA ligase (NAD+) activity	IEA	Interproscan
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006260	DNA replication	IEA	Interproscan
BP	GO:0006281	DNA repair	IEA	Interproscan
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006950	response to stress	None	Extended
BP	GO:0006974	cellular response to DNA damage stimulus	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009059	macromolecule biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016874	ligase activity	None	Extended
MF	GO:0016886	ligase activity, forming phosphoric ester bonds	None	Extended
BP	GO:0033554	cellular response to stress	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034645	cellular macromolecule biosynthetic process	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051716	cellular response to stimulus	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0140097	catalytic activity, acting on DNA	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0003887	DNA-directed DNA polymerase activity	IEP	Enrichment
CC	GO:0005575	cellular_component	IEP	Enrichment
MF	GO:0008144	drug binding	IEP	Enrichment
MF	GO:0008658	penicillin binding	IEP	Enrichment
MF	GO:0015099	nickel cation transmembrane transporter activity	IEP	Enrichment
BP	GO:0015675	nickel cation transport	IEP	Enrichment
CC	GO:0016020	membrane	IEP	Enrichment
CC	GO:0016021	integral component of membrane	IEP	Enrichment
CC	GO:0031224	intrinsic component of membrane	IEP	Enrichment
MF	GO:0031406	carboxylic acid binding	IEP	Enrichment
MF	GO:0032977	membrane insertase activity	IEP	Enrichment
MF	GO:0033218	amide binding	IEP	Enrichment
MF	GO:0033293	monocarboxylic acid binding	IEP	Enrichment
MF	GO:0034061	DNA polymerase activity	IEP	Enrichment
BP	GO:0035444	nickel cation transmembrane transport	IEP	Enrichment
MF	GO:0042910	xenobiotic transmembrane transporter activity	IEP	Enrichment
MF	GO:0043177	organic acid binding	IEP	Enrichment
BP	GO:0051301	cell division	IEP	Enrichment
BP	GO:0055085	transmembrane transport	IEP	Enrichment
MF	GO:0097367	carbohydrate derivative binding	IEP	Enrichment
CC	GO:0110165	cellular anatomical entity	IEP	Enrichment
MF	GO:0140104	molecular carrier activity	IEP	Enrichment
MF	GO:0140597	protein carrier activity	IEP	Enrichment

InterPro domains	Description	Start	Stop
IPR041663	DisA/LigA_HHH	511	574
IPR013839	DNAligase_adenylation	3	319
IPR001357	BRCT_dom	594	666
IPR004150	NAD_DNA_ligase_OB	323	399
IPR004149	Znf_DNAligase_C4	408	435

External Links

No external refs found!

EDJ91896 (ligA, CGSHi22421_09073)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation