AAL23012 (STM4188, metH)

Aliases : STM4188, metH

Description : B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase [Ensembl]. B12 binding domain, Pterin binding enzyme, Homocysteine S-methyltransferase, Vitamin B12 dependent methionine synthase [Interproscan].

Gene families : OG_02_0000961 (OrthoFinder) Phylogenetic Tree(s): OG0000961_tree

Sequence : coding (download), protein (download)

Download

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: AAL23012
Cluster	HCCA: Cluster_10

Target	Alias	Description	ECC score	Gene Family Method
AAC73364	mmuM, b0261	CP4-6 prophage; S-methylmethionine:homocysteine...	0.2	OrthoFinder
AGT25728	N559_4102	homocysteine methyltransferase [Ensembl]....	0.07	OrthoFinder
AKI49674	L2625_01789	bifunctional homocysteine S-methyltransferase...	0.06	OrthoFinder
CCL20729	BN171_960021	Bifunctional carbon monoxide dehydrogenase/acetyl-CoA...	0.04	OrthoFinder
CPC90060	metH, ERS093114_01571	5%2C10-methylenetetrahydrofolate reductase-like...	0.02	OrthoFinder
CRO36716	metH	Methionine synthase [Ensembl]. B12 binding domain,...	0.03	OrthoFinder

Type	GO Term	Name	Evidence	Source
BP	GO:0000096	sulfur amino acid metabolic process	None	Extended
BP	GO:0000097	sulfur amino acid biosynthetic process	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0005488	binding	None	Extended
BP	GO:0006082	organic acid metabolic process	None	Extended
BP	GO:0006520	cellular amino acid metabolic process	None	Extended
BP	GO:0006555	methionine metabolic process	None	Extended
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006790	sulfur compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008168	methyltransferase activity	None	Extended
MF	GO:0008172	S-methyltransferase activity	None	Extended
BP	GO:0008652	cellular amino acid biosynthetic process	None	Extended
MF	GO:0008705	methionine synthase activity	IEA	Interproscan
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009066	aspartate family amino acid metabolic process	None	Extended
BP	GO:0009067	aspartate family amino acid biosynthetic process	None	Extended
BP	GO:0009086	methionine biosynthetic process	IEA	Interproscan
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016053	organic acid biosynthetic process	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016741	transferase activity, transferring one-carbon groups	None	Extended
BP	GO:0019752	carboxylic acid metabolic process	None	Extended
MF	GO:0019842	vitamin binding	None	Extended
MF	GO:0031419	cobalamin binding	IEA	Interproscan
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0042084	5-methyltetrahydrofolate-dependent methyltransferase activity	None	Extended
BP	GO:0042558	pteridine-containing compound metabolic process	IEA	Interproscan
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043169	cation binding	None	Extended
BP	GO:0043436	oxoacid metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044272	sulfur compound biosynthetic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0044283	small molecule biosynthetic process	None	Extended
BP	GO:0046394	carboxylic acid biosynthetic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
MF	GO:0046872	metal ion binding	IEA	Interproscan
MF	GO:0046906	tetrapyrrole binding	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901566	organonitrogen compound biosynthetic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended
BP	GO:1901605	alpha-amino acid metabolic process	None	Extended
BP	GO:1901607	alpha-amino acid biosynthetic process	None	Extended

Toggle parental

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	IEP	Enrichment
MF	GO:0003871	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity	IEP	Enrichment
MF	GO:0004417	hydroxyethylthiazole kinase activity	IEP	Enrichment
MF	GO:0004486	methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity	IEP	Enrichment
MF	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	IEP	Enrichment
MF	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	IEP	Enrichment
MF	GO:0004611	phosphoenolpyruvate carboxykinase activity	IEP	Enrichment
BP	GO:0006534	cysteine metabolic process	IEP	Enrichment
BP	GO:0006536	glutamate metabolic process	IEP	Enrichment
BP	GO:0006537	glutamate biosynthetic process	IEP	Enrichment
BP	GO:0006553	lysine metabolic process	IEP	Enrichment
BP	GO:0006772	thiamine metabolic process	IEP	Enrichment
BP	GO:0006810	transport	IEP	Enrichment
MF	GO:0008839	4-hydroxy-tetrahydrodipicolinate reductase	IEP	Enrichment
MF	GO:0008964	phosphoenolpyruvate carboxylase activity	IEP	Enrichment
BP	GO:0009069	serine family amino acid metabolic process	IEP	Enrichment
BP	GO:0009084	glutamine family amino acid biosynthetic process	IEP	Enrichment
BP	GO:0009085	lysine biosynthetic process	IEP	Enrichment
BP	GO:0009089	lysine biosynthetic process via diaminopimelate	IEP	Enrichment
BP	GO:0009092	homoserine metabolic process	IEP	Enrichment
BP	GO:0009228	thiamine biosynthetic process	IEP	Enrichment
BP	GO:0015833	peptide transport	IEP	Enrichment
MF	GO:0015930	glutamate synthase activity	IEP	Enrichment
BP	GO:0015977	carbon fixation	IEP	Enrichment
CC	GO:0016020	membrane	IEP	Enrichment
MF	GO:0016491	oxidoreductase activity	IEP	Enrichment
MF	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	IEP	Enrichment
MF	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	IEP	Enrichment
MF	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	IEP	Enrichment
MF	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	IEP	Enrichment
MF	GO:0016887	ATPase	IEP	Enrichment
BP	GO:0019346	transsulfuration	IEP	Enrichment
MF	GO:0030170	pyridoxal phosphate binding	IEP	Enrichment
MF	GO:0042085	5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity	IEP	Enrichment
BP	GO:0042723	thiamine-containing compound metabolic process	IEP	Enrichment
BP	GO:0042724	thiamine-containing compound biosynthetic process	IEP	Enrichment
BP	GO:0042886	amide transport	IEP	Enrichment
MF	GO:0043168	anion binding	IEP	Enrichment
BP	GO:0043648	dicarboxylic acid metabolic process	IEP	Enrichment
BP	GO:0043650	dicarboxylic acid biosynthetic process	IEP	Enrichment
BP	GO:0046451	diaminopimelate metabolic process	IEP	Enrichment
MF	GO:0050661	NADP binding	IEP	Enrichment
BP	GO:0050667	homocysteine metabolic process	IEP	Enrichment
BP	GO:0051179	localization	IEP	Enrichment
BP	GO:0051234	establishment of localization	IEP	Enrichment
BP	GO:0055085	transmembrane transport	IEP	Enrichment
BP	GO:0055114	obsolete oxidation-reduction process	IEP	Enrichment
MF	GO:0070279	vitamin B6 binding	IEP	Enrichment
BP	GO:0072527	pyrimidine-containing compound metabolic process	IEP	Enrichment
BP	GO:0072528	pyrimidine-containing compound biosynthetic process	IEP	Enrichment
MF	GO:1901265	nucleoside phosphate binding	IEP	Enrichment

InterPro domains	Description	Start	Stop
IPR004223	VitB12-dep_Met_synth_activ_dom	967	1237
IPR003726	HCY_dom	46	354
IPR000489	Pterin-binding_dom	389	627
IPR003759	Cbl-bd_cap	689	762
IPR006158	Cobalamin-bd	777	869

External Links

No external refs found!

AAL23012 (STM4188, metH)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation