AAL00374 (spr1571, mvaS)

Aliases : spr1571, mvaS

Description : 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase [Ensembl]. Hydroxymethylglutaryl-coenzyme A synthase N terminal, Hydroxymethylglutaryl-coenzyme A synthase C terminal [Interproscan].

Gene families : OG_02_0002535 (OrthoFinder) Phylogenetic Tree(s): OG0002535_tree

Sequence : coding (download), protein (download)

Download

Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: AAL00374
Cluster	HCCA: Cluster_3

Target	Alias	Description	ECC score	Gene Family Method
AKI49412	mvaS, L2625_01512	hydroxymethylglutaryl-CoA synthase [Ensembl]....	0.06	OrthoFinder
CCG27078	No alias	Hydroxymethylglutaryl-CoA synthase [Ensembl]. Chalcone...	0.06	OrthoFinder
CPC63667	mvaS, ERS093114_00915	Hydroxymethylglutaryl-CoA synthase [Ensembl]....	0.05	OrthoFinder

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004421	hydroxymethylglutaryl-CoA synthase activity	IEA	Interproscan
BP	GO:0006629	lipid metabolic process	None	Extended
BP	GO:0006720	isoprenoid metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0008299	isoprenoid biosynthetic process	IEA	Interproscan
BP	GO:0008610	lipid biosynthetic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016746	acyltransferase activity	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044255	cellular lipid metabolic process	None	Extended
MF	GO:0046912	acyltransferase, acyl groups converted into alkyl on transfer	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

Toggle parental

Type	GO Term	Name	Evidence	Source
MF	GO:0000287	magnesium ion binding	IEP	Enrichment
MF	GO:0003848	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity	IEP	Enrichment
MF	GO:0004107	chorismate synthase activity	IEP	Enrichment
MF	GO:0004127	cytidylate kinase activity	IEP	Enrichment
MF	GO:0004150	dihydroneopterin aldolase activity	IEP	Enrichment
MF	GO:0004347	glucose-6-phosphate isomerase activity	IEP	Enrichment
MF	GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	IEP	Enrichment
MF	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	IEP	Enrichment
MF	GO:0004618	phosphoglycerate kinase activity	IEP	Enrichment
MF	GO:0004743	pyruvate kinase activity	IEP	Enrichment
MF	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IEP	Enrichment
MF	GO:0004784	superoxide dismutase activity	IEP	Enrichment
MF	GO:0004812	aminoacyl-tRNA ligase activity	IEP	Enrichment
MF	GO:0004832	valine-tRNA ligase activity	IEP	Enrichment
MF	GO:0005488	binding	IEP	Enrichment
BP	GO:0006082	organic acid metabolic process	IEP	Enrichment
BP	GO:0006090	pyruvate metabolic process	IEP	Enrichment
BP	GO:0006091	generation of precursor metabolites and energy	IEP	Enrichment
BP	GO:0006096	glycolytic process	IEP	Enrichment
BP	GO:0006098	pentose-phosphate shunt	IEP	Enrichment
BP	GO:0006163	purine nucleotide metabolic process	IEP	Enrichment
BP	GO:0006165	nucleoside diphosphate phosphorylation	IEP	Enrichment
BP	GO:0006399	tRNA metabolic process	IEP	Enrichment
BP	GO:0006418	tRNA aminoacylation for protein translation	IEP	Enrichment
BP	GO:0006520	cellular amino acid metabolic process	IEP	Enrichment
BP	GO:0006553	lysine metabolic process	IEP	Enrichment
BP	GO:0006605	protein targeting	IEP	Enrichment
BP	GO:0006612	protein targeting to membrane	IEP	Enrichment
BP	GO:0006613	cotranslational protein targeting to membrane	IEP	Enrichment
BP	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	IEP	Enrichment
BP	GO:0006739	NADP metabolic process	IEP	Enrichment
BP	GO:0006740	NADPH regeneration	IEP	Enrichment
BP	GO:0006757	ATP generation from ADP	IEP	Enrichment
BP	GO:0006801	superoxide metabolic process	IEP	Enrichment
BP	GO:0006886	intracellular protein transport	IEP	Enrichment
BP	GO:0008104	protein localization	IEP	Enrichment
MF	GO:0008270	zinc ion binding	IEP	Enrichment
MF	GO:0008312	7S RNA binding	IEP	Enrichment
MF	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	IEP	Enrichment
MF	GO:0008839	4-hydroxy-tetrahydrodipicolinate reductase	IEP	Enrichment
BP	GO:0009067	aspartate family amino acid biosynthetic process	IEP	Enrichment
BP	GO:0009085	lysine biosynthetic process	IEP	Enrichment
BP	GO:0009089	lysine biosynthetic process via diaminopimelate	IEP	Enrichment
BP	GO:0009132	nucleoside diphosphate metabolic process	IEP	Enrichment
BP	GO:0009135	purine nucleoside diphosphate metabolic process	IEP	Enrichment
BP	GO:0009150	purine ribonucleotide metabolic process	IEP	Enrichment
BP	GO:0009179	purine ribonucleoside diphosphate metabolic process	IEP	Enrichment
BP	GO:0009185	ribonucleoside diphosphate metabolic process	IEP	Enrichment
BP	GO:0009259	ribonucleotide metabolic process	IEP	Enrichment
BP	GO:0015031	protein transport	IEP	Enrichment
BP	GO:0015936	coenzyme A metabolic process	IEP	Enrichment
BP	GO:0016052	carbohydrate catabolic process	IEP	Enrichment
MF	GO:0016491	oxidoreductase activity	IEP	Enrichment
MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	IEP	Enrichment
MF	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEP	Enrichment
MF	GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	IEP	Enrichment
MF	GO:0016774	phosphotransferase activity, carboxyl group as acceptor	IEP	Enrichment
MF	GO:0016776	phosphotransferase activity, phosphate group as acceptor	IEP	Enrichment
MF	GO:0016778	diphosphotransferase activity	IEP	Enrichment
MF	GO:0016832	aldehyde-lyase activity	IEP	Enrichment
MF	GO:0016838	carbon-oxygen lyase activity, acting on phosphates	IEP	Enrichment
MF	GO:0016874	ligase activity	IEP	Enrichment
MF	GO:0016875	ligase activity, forming carbon-oxygen bonds	IEP	Enrichment
BP	GO:0019637	organophosphate metabolic process	IEP	Enrichment
BP	GO:0019693	ribose phosphate metabolic process	IEP	Enrichment
BP	GO:0019725	cellular homeostasis	IEP	Enrichment
BP	GO:0019752	carboxylic acid metabolic process	IEP	Enrichment
BP	GO:0032787	monocarboxylic acid metabolic process	IEP	Enrichment
BP	GO:0033036	macromolecule localization	IEP	Enrichment
BP	GO:0033365	protein localization to organelle	IEP	Enrichment
BP	GO:0033865	nucleoside bisphosphate metabolic process	IEP	Enrichment
BP	GO:0033875	ribonucleoside bisphosphate metabolic process	IEP	Enrichment
BP	GO:0034032	purine nucleoside bisphosphate metabolic process	IEP	Enrichment
BP	GO:0034613	cellular protein localization	IEP	Enrichment
MF	GO:0036094	small molecule binding	IEP	Enrichment
BP	GO:0042592	homeostatic process	IEP	Enrichment
BP	GO:0043038	amino acid activation	IEP	Enrichment
BP	GO:0043039	tRNA aminoacylation	IEP	Enrichment
MF	GO:0043167	ion binding	IEP	Enrichment
MF	GO:0043168	anion binding	IEP	Enrichment
MF	GO:0043169	cation binding	IEP	Enrichment
BP	GO:0043436	oxoacid metabolic process	IEP	Enrichment
BP	GO:0043648	dicarboxylic acid metabolic process	IEP	Enrichment
BP	GO:0044281	small molecule metabolic process	IEP	Enrichment
BP	GO:0045047	protein targeting to ER	IEP	Enrichment
BP	GO:0045184	establishment of protein localization	IEP	Enrichment
BP	GO:0045454	cell redox homeostasis	IEP	Enrichment
BP	GO:0046031	ADP metabolic process	IEP	Enrichment
BP	GO:0046394	carboxylic acid biosynthetic process	IEP	Enrichment
BP	GO:0046451	diaminopimelate metabolic process	IEP	Enrichment
MF	GO:0046872	metal ion binding	IEP	Enrichment
BP	GO:0046907	intracellular transport	IEP	Enrichment
BP	GO:0046939	nucleotide phosphorylation	IEP	Enrichment
CC	GO:0048500	signal recognition particle	IEP	Enrichment
MF	GO:0050145	nucleoside monophosphate kinase activity	IEP	Enrichment
BP	GO:0051156	glucose 6-phosphate metabolic process	IEP	Enrichment
BP	GO:0051641	cellular localization	IEP	Enrichment
BP	GO:0051649	establishment of localization in cell	IEP	Enrichment
BP	GO:0051668	localization within membrane	IEP	Enrichment
BP	GO:0055114	obsolete oxidation-reduction process	IEP	Enrichment
MF	GO:0061731	ribonucleoside-diphosphate reductase activity	IEP	Enrichment
BP	GO:0065008	regulation of biological quality	IEP	Enrichment
BP	GO:0070727	cellular macromolecule localization	IEP	Enrichment
BP	GO:0070972	protein localization to endoplasmic reticulum	IEP	Enrichment
BP	GO:0072593	reactive oxygen species metabolic process	IEP	Enrichment
BP	GO:0072594	establishment of protein localization to organelle	IEP	Enrichment
BP	GO:0072599	establishment of protein localization to endoplasmic reticulum	IEP	Enrichment
BP	GO:0072657	protein localization to membrane	IEP	Enrichment
BP	GO:0090150	establishment of protein localization to membrane	IEP	Enrichment
MF	GO:0140098	catalytic activity, acting on RNA	IEP	Enrichment
MF	GO:0140101	catalytic activity, acting on a tRNA	IEP	Enrichment
BP	GO:1901135	carbohydrate derivative metabolic process	IEP	Enrichment
BP	GO:1901564	organonitrogen compound metabolic process	IEP	Enrichment
CC	GO:1990904	ribonucleoprotein complex	IEP	Enrichment

InterPro domains	Description	Start	Stop
IPR013746	HMG_CoA_synt_C_dom	254	357
IPR013528	HMG_CoA_synth_N	19	172

External Links

No external refs found!

AAL00374 (spr1571, mvaS)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation