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GO:0003918: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity (Molecular function)

"Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [PMID:8811192]


There are 1157 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_8 Campylobacter jejuni 1.36 % 0.008033 0.04701
Cluster_38 Clostridioides difficile 2.82 % 0.00035 0.029047
Cluster_41 Escherichia coli 3.45 % 3.5e-05 0.000525
Cluster_44 Klebsiella pneumoniae 2.99 % 0.0 4e-06
Cluster_18 Listeria monocytogenes 1.52 % 0.012288 0.045378
Cluster_1 Mycobacterium tuberculosis 1.46 % 0.001154 0.00594
Cluster_35 Pseudomonas aeruginosa 1.5 % 0.000112 0.001623
Cluster_23 Staphylococcus aureus 3.77 % 0.001173 0.046929
Sequences (1157) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro Domains

Family Terms