CPD08084 (leuA_2, ERS093114_02010)

Aliases : leuA_2, ERS093114_02010

Description : 2-isopropylmalate synthase [Ensembl]. HMGL-like, LeuA allosteric (dimerisation) domain [Interproscan].

Gene families : OG_02_0000655 (OrthoFinder) Phylogenetic Tree(s): OG0000655_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: CPD08084
Cluster	HCCA: Cluster_1

Target	Alias	Description	ECC score	Gene Family Method
AAC73185	leuA, b0074	2-isopropylmalate synthase [Ensembl]. HMGL-like, LeuA...	0.09	OrthoFinder
AAK99939	spr1136	2-isopropylmalate synthase, truncation [Ensembl]. LeuA...	0.03	OrthoFinder
AAK99940	spr1137	2-isopropylmalate synthase, truncation [Ensembl]....	0.03	OrthoFinder
AAL19077	STM0113, leuA	2-isopropylmalate synthase [Ensembl]. HMGL-like, LeuA...	0.12	OrthoFinder
AGT25961	N559_4351	2-isopropylmalate synthase [Ensembl]. LeuA allosteric...	0.1	OrthoFinder
AHY40904	CJ8421_08660	2-isopropylmalate synthase [Ensembl]. HMGL-like, LeuA...	0.03	OrthoFinder
AKI49982	leuA, L2625_02135	2-isopropylmalate synthase [Ensembl]. Pyruvate...	0.12	OrthoFinder
EDJ91783	CGSHi22421_08508	2-isopropylmalate synthase [Ensembl]. HMGL-like [Interproscan].	0.03	OrthoFinder
KNA51159	VCV51_031676	2-isopropylmalate synthase [Ensembl]. HMGL-like, LeuA...	0.1	OrthoFinder

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	IEA	Interproscan
MF	GO:0003852	2-isopropylmalate synthase activity	IEA	Interproscan
BP	GO:0006082	organic acid metabolic process	None	Extended
BP	GO:0006520	cellular amino acid metabolic process	None	Extended
BP	GO:0006551	leucine metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0008652	cellular amino acid biosynthetic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009098	leucine biosynthetic process	IEA	Interproscan
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016053	organic acid biosynthetic process	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016746	acyltransferase activity	None	Extended
BP	GO:0019752	carboxylic acid metabolic process	None	Extended
BP	GO:0043436	oxoacid metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0044283	small molecule biosynthetic process	None	Extended
BP	GO:0046394	carboxylic acid biosynthetic process	None	Extended
MF	GO:0046912	acyltransferase, acyl groups converted into alkyl on transfer	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901566	organonitrogen compound biosynthetic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000097	sulfur amino acid biosynthetic process	IEP	Enrichment
MF	GO:0000166	nucleotide binding	IEP	Enrichment
MF	GO:0003871	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity	IEP	Enrichment
MF	GO:0004455	ketol-acid reductoisomerase activity	IEP	Enrichment
MF	GO:0005215	transporter activity	IEP	Enrichment
MF	GO:0005283	amino acid:sodium symporter activity	IEP	Enrichment
MF	GO:0005310	dicarboxylic acid transmembrane transporter activity	IEP	Enrichment
MF	GO:0005342	organic acid transmembrane transporter activity	IEP	Enrichment
MF	GO:0005343	organic acid:sodium symporter activity	IEP	Enrichment
MF	GO:0005416	amino acid:cation symporter activity	IEP	Enrichment
MF	GO:0005524	ATP binding	IEP	Enrichment
BP	GO:0006555	methionine metabolic process	IEP	Enrichment
BP	GO:0006810	transport	IEP	Enrichment
BP	GO:0006811	ion transport	IEP	Enrichment
BP	GO:0006814	sodium ion transport	IEP	Enrichment
BP	GO:0006820	anion transport	IEP	Enrichment
BP	GO:0006835	dicarboxylic acid transport	IEP	Enrichment
BP	GO:0006857	oligopeptide transport	IEP	Enrichment
MF	GO:0008172	S-methyltransferase activity	IEP	Enrichment
MF	GO:0008509	anion transmembrane transporter activity	IEP	Enrichment
MF	GO:0008514	organic anion transmembrane transporter activity	IEP	Enrichment
BP	GO:0009066	aspartate family amino acid metabolic process	IEP	Enrichment
BP	GO:0009067	aspartate family amino acid biosynthetic process	IEP	Enrichment
BP	GO:0009081	branched-chain amino acid metabolic process	IEP	Enrichment
BP	GO:0009082	branched-chain amino acid biosynthetic process	IEP	Enrichment
BP	GO:0009086	methionine biosynthetic process	IEP	Enrichment
MF	GO:0015075	ion transmembrane transporter activity	IEP	Enrichment
MF	GO:0015081	sodium ion transmembrane transporter activity	IEP	Enrichment
MF	GO:0015175	neutral amino acid transmembrane transporter activity	IEP	Enrichment
MF	GO:0015291	secondary active transmembrane transporter activity	IEP	Enrichment
MF	GO:0015294	solute:cation symporter activity	IEP	Enrichment
MF	GO:0015370	solute:sodium symporter activity	IEP	Enrichment
MF	GO:0015558	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity	IEP	Enrichment
MF	GO:0015655	alanine:sodium symporter activity	IEP	Enrichment
BP	GO:0015711	organic anion transport	IEP	Enrichment
BP	GO:0015804	neutral amino acid transport	IEP	Enrichment
BP	GO:0015814	p-aminobenzoyl-glutamate transport	IEP	Enrichment
BP	GO:0015833	peptide transport	IEP	Enrichment
BP	GO:0015849	organic acid transport	IEP	Enrichment
CC	GO:0016020	membrane	IEP	Enrichment
MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	IEP	Enrichment
MF	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEP	Enrichment
MF	GO:0016887	ATPase	IEP	Enrichment
MF	GO:0017076	purine nucleotide binding	IEP	Enrichment
MF	GO:0022804	active transmembrane transporter activity	IEP	Enrichment
MF	GO:0022853	active ion transmembrane transporter activity	IEP	Enrichment
MF	GO:0022857	transmembrane transporter activity	IEP	Enrichment
MF	GO:0022858	alanine transmembrane transporter activity	IEP	Enrichment
MF	GO:0030554	adenyl nucleotide binding	IEP	Enrichment
BP	GO:0032328	alanine transport	IEP	Enrichment
MF	GO:0032553	ribonucleotide binding	IEP	Enrichment
MF	GO:0032555	purine ribonucleotide binding	IEP	Enrichment
MF	GO:0032559	adenyl ribonucleotide binding	IEP	Enrichment
BP	GO:0035442	dipeptide transmembrane transport	IEP	Enrichment
MF	GO:0035639	purine ribonucleoside triphosphate binding	IEP	Enrichment
BP	GO:0035672	oligopeptide transmembrane transport	IEP	Enrichment
MF	GO:0035673	oligopeptide transmembrane transporter activity	IEP	Enrichment
MF	GO:0036094	small molecule binding	IEP	Enrichment
MF	GO:0042085	5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity	IEP	Enrichment
BP	GO:0042886	amide transport	IEP	Enrichment
MF	GO:0042887	amide transmembrane transporter activity	IEP	Enrichment
BP	GO:0042938	dipeptide transport	IEP	Enrichment
MF	GO:0043167	ion binding	IEP	Enrichment
MF	GO:0043168	anion binding	IEP	Enrichment
BP	GO:0046942	carboxylic acid transport	IEP	Enrichment
MF	GO:0046943	carboxylic acid transmembrane transporter activity	IEP	Enrichment
BP	GO:0051179	localization	IEP	Enrichment
BP	GO:0051234	establishment of localization	IEP	Enrichment
BP	GO:0055085	transmembrane transport	IEP	Enrichment
BP	GO:0071702	organic substance transport	IEP	Enrichment
BP	GO:0071705	nitrogen compound transport	IEP	Enrichment
MF	GO:0071916	dipeptide transmembrane transporter activity	IEP	Enrichment
BP	GO:0072337	modified amino acid transport	IEP	Enrichment
MF	GO:0072349	modified amino acid transmembrane transporter activity	IEP	Enrichment
MF	GO:0097159	organic cyclic compound binding	IEP	Enrichment
MF	GO:0097367	carbohydrate derivative binding	IEP	Enrichment
BP	GO:0098656	anion transmembrane transport	IEP	Enrichment
MF	GO:1901265	nucleoside phosphate binding	IEP	Enrichment
MF	GO:1901363	heterocyclic compound binding	IEP	Enrichment
BP	GO:1902604	p-aminobenzoyl-glutamate transmembrane transport	IEP	Enrichment
BP	GO:1903825	organic acid transmembrane transport	IEP	Enrichment
MF	GO:1904680	peptide transmembrane transporter activity	IEP	Enrichment
BP	GO:1905039	carboxylic acid transmembrane transport	IEP	Enrichment

InterPro domains	Description	Start	Stop
IPR000891	PYR_CT	5	273
IPR013709	2-isopropylmalate_synth_dimer	370	499

External Links

No external refs found!

CPD08084 (leuA_2, ERS093114_02010)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation