CCP45240 (folC, Rv2447c)


Aliases : folC, Rv2447c

Description : Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) [Ensembl]. Mur ligase family, Mur ligase middle domain [Interproscan].


Gene families : OG_02_0000331 (OrthoFinder) Phylogenetic Tree(s): OG0000331_tree

Sequence : coding (download), protein (download)


Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: CCP45240
Cluster HCCA: Cluster_37

Target Alias Description ECC score Gene Family Method Actions
AKI49548 folC, L2625_01655 folylpolyglutamate synthase [Ensembl]. Mur ligase [Interproscan]. 0.03 OrthoFinder
AKP15641 folC, WX61_01603 Bifunctional protein FolC [Ensembl]. Mur ligase middle... 0.02 OrthoFinder
CCL19735 folC, BN171_3440010 Folylpolyglutamate synthase [Ensembl]. Mur ligase... 0.02 OrthoFinder
CPC85166 folC, ERS093114_01484 Dihydrofolate synthase / Folylpolyglutamate synthase... 0.04 OrthoFinder
KNA56234 VCV51_030704 folylpolyglutamate synthase/dihydrofolate synthase... 0.03 OrthoFinder

Type GO Term Name Evidence Source
MF GO:0005524 ATP binding IEA Interproscan
BP GO:0009058 biosynthetic process IEA Interproscan
MF GO:0016874 ligase activity IEA Interproscan
Type GO Term Name Evidence Source
MF GO:0000049 tRNA binding IEP Enrichment
BP GO:0000097 sulfur amino acid biosynthetic process IEP Enrichment
BP GO:0000105 histidine biosynthetic process IEP Enrichment
MF GO:0000287 magnesium ion binding IEP Enrichment
BP GO:0001510 RNA methylation IEP Enrichment
MF GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity IEP Enrichment
MF GO:0004177 aminopeptidase activity IEP Enrichment
MF GO:0004180 carboxypeptidase activity IEP Enrichment
MF GO:0004185 serine-type carboxypeptidase activity IEP Enrichment
MF GO:0004352 glutamate dehydrogenase (NAD+) activity IEP Enrichment
MF GO:0004353 glutamate dehydrogenase [NAD(P)+] activity IEP Enrichment
MF GO:0004486 methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity IEP Enrichment
MF GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity IEP Enrichment
MF GO:0004812 aminoacyl-tRNA ligase activity IEP Enrichment
MF GO:0004826 phenylalanine-tRNA ligase activity IEP Enrichment
MF GO:0004832 valine-tRNA ligase activity IEP Enrichment
CC GO:0005737 cytoplasm IEP Enrichment
BP GO:0006082 organic acid metabolic process IEP Enrichment
BP GO:0006099 tricarboxylic acid cycle IEP Enrichment
BP GO:0006103 2-oxoglutarate metabolic process IEP Enrichment
BP GO:0006106 fumarate metabolic process IEP Enrichment
BP GO:0006399 tRNA metabolic process IEP Enrichment
BP GO:0006400 tRNA modification IEP Enrichment
BP GO:0006418 tRNA aminoacylation for protein translation IEP Enrichment
BP GO:0006432 phenylalanyl-tRNA aminoacylation IEP Enrichment
BP GO:0006438 valyl-tRNA aminoacylation IEP Enrichment
BP GO:0006520 cellular amino acid metabolic process IEP Enrichment
BP GO:0006536 glutamate metabolic process IEP Enrichment
BP GO:0006538 glutamate catabolic process IEP Enrichment
BP GO:0006547 histidine metabolic process IEP Enrichment
BP GO:0006555 methionine metabolic process IEP Enrichment
BP GO:0006807 nitrogen compound metabolic process IEP Enrichment
MF GO:0008175 tRNA methyltransferase activity IEP Enrichment
MF GO:0008238 exopeptidase activity IEP Enrichment
BP GO:0008652 cellular amino acid biosynthetic process IEP Enrichment
MF GO:0008757 S-adenosylmethionine-dependent methyltransferase activity IEP Enrichment
MF GO:0008897 holo-[acyl-carrier-protein] synthase activity IEP Enrichment
BP GO:0009065 glutamine family amino acid catabolic process IEP Enrichment
BP GO:0009086 methionine biosynthetic process IEP Enrichment
BP GO:0016053 organic acid biosynthetic process IEP Enrichment
BP GO:0016070 RNA metabolic process IEP Enrichment
MF GO:0016426 tRNA (adenine) methyltransferase activity IEP Enrichment
MF GO:0016429 tRNA (adenine-N1-)-methyltransferase activity IEP Enrichment
MF GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors IEP Enrichment
MF GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor IEP Enrichment
MF GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors IEP Enrichment
MF GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor IEP Enrichment
MF GO:0016780 phosphotransferase activity, for other substituted phosphate groups IEP Enrichment
MF GO:0016875 ligase activity, forming carbon-oxygen bonds IEP Enrichment
BP GO:0019551 glutamate catabolic process to 2-oxoglutarate IEP Enrichment
BP GO:0019752 carboxylic acid metabolic process IEP Enrichment
BP GO:0030488 tRNA methylation IEP Enrichment
CC GO:0031515 tRNA (m1A) methyltransferase complex IEP Enrichment
BP GO:0034660 ncRNA metabolic process IEP Enrichment
CC GO:0034708 methyltransferase complex IEP Enrichment
MF GO:0042085 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity IEP Enrichment
BP GO:0043038 amino acid activation IEP Enrichment
BP GO:0043039 tRNA aminoacylation IEP Enrichment
MF GO:0043169 cation binding IEP Enrichment
BP GO:0043414 macromolecule methylation IEP Enrichment
BP GO:0043436 oxoacid metabolic process IEP Enrichment
CC GO:0043527 tRNA methyltransferase complex IEP Enrichment
BP GO:0043649 dicarboxylic acid catabolic process IEP Enrichment
BP GO:0044237 cellular metabolic process IEP Enrichment
BP GO:0044238 primary metabolic process IEP Enrichment
BP GO:0044281 small molecule metabolic process IEP Enrichment
BP GO:0044283 small molecule biosynthetic process IEP Enrichment
BP GO:0046394 carboxylic acid biosynthetic process IEP Enrichment
MF GO:0046872 metal ion binding IEP Enrichment
BP GO:0071704 organic substance metabolic process IEP Enrichment
MF GO:0140098 catalytic activity, acting on RNA IEP Enrichment
MF GO:0140101 catalytic activity, acting on a tRNA IEP Enrichment
BP GO:1901564 organonitrogen compound metabolic process IEP Enrichment
BP GO:1901605 alpha-amino acid metabolic process IEP Enrichment
CC GO:1990234 transferase complex IEP Enrichment
InterPro domains Description Start Stop
IPR013221 Mur_ligase_cen 69 308
IPR004101 Mur_ligase_C 336 413
UniProtKB I6Y0R5