AEA93146 (ligA, OG1RF_10459)


Aliases : ligA, OG1RF_10459

Description : NAD-dependent DNA ligase LigA [Ensembl]. Helix-hairpin-helix motif, Helix-hairpin-helix domain, BRCA1 C Terminus (BRCT) domain, NAD-dependent DNA ligase OB-fold domain, NAD-dependent DNA ligase adenylation domain, NAD-dependent DNA ligase C4 zinc finger domain [Interproscan].


Gene families : OG_02_0000445 (OrthoFinder) Phylogenetic Tree(s): OG0000445_tree

Sequence : coding (download), protein (download)


Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: AEA93146
Cluster HCCA: Cluster_7

Target Alias Description ECC score Gene Family Method Actions
AAK99828 spr1024, ligA DNA ligase [Ensembl]. Helix-hairpin-helix motif,... 0.06 OrthoFinder
ADK87023 ligA, MPNE_0413 DNA ligase (NAD(+)) [Ensembl]. NAD-dependent DNA ligase... 0.03 OrthoFinder
AKP15609 ligA_2, WX61_01570 DNA ligase [Ensembl]. Helix-hairpin-helix motif, BRCA1 C... 0.04 OrthoFinder
CCG26397 No alias DNA ligase [Ensembl]. Helix-hairpin-helix motif,... 0.05 OrthoFinder
CPD03240 lig, ERS093114_01872 DNA ligase [Ensembl]. Helix-hairpin-helix motif,... 0.05 OrthoFinder
CRP54066 ligA DNA ligase [Ensembl]. Helix-hairpin-helix motif, BRCA1 C... 0.04 OrthoFinder

Type GO Term Name Evidence Source
MF GO:0003911 DNA ligase (NAD+) activity IEA Interproscan
BP GO:0006260 DNA replication IEA Interproscan
BP GO:0006281 DNA repair IEA Interproscan
Type GO Term Name Evidence Source
MF GO:0000166 nucleotide binding IEP Enrichment
BP GO:0001522 pseudouridine synthesis IEP Enrichment
MF GO:0003690 double-stranded DNA binding IEP Enrichment
MF GO:0003723 RNA binding IEP Enrichment
MF GO:0003725 double-stranded RNA binding IEP Enrichment
MF GO:0003919 FMN adenylyltransferase activity IEP Enrichment
MF GO:0003951 NAD+ kinase activity IEP Enrichment
MF GO:0003989 acetyl-CoA carboxylase activity IEP Enrichment
MF GO:0004329 formate-tetrahydrofolate ligase activity IEP Enrichment
MF GO:0005488 binding IEP Enrichment
MF GO:0005524 ATP binding IEP Enrichment
BP GO:0006298 mismatch repair IEP Enrichment
BP GO:0006468 protein phosphorylation IEP Enrichment
BP GO:0006741 NADP biosynthetic process IEP Enrichment
BP GO:0006771 riboflavin metabolic process IEP Enrichment
MF GO:0008168 methyltransferase activity IEP Enrichment
MF GO:0008531 riboflavin kinase activity IEP Enrichment
BP GO:0008610 lipid biosynthetic process IEP Enrichment
MF GO:0008839 4-hydroxy-tetrahydrodipicolinate reductase IEP Enrichment
BP GO:0009231 riboflavin biosynthetic process IEP Enrichment
CC GO:0009317 acetyl-CoA carboxylase complex IEP Enrichment
BP GO:0009451 RNA modification IEP Enrichment
MF GO:0009982 pseudouridine synthase activity IEP Enrichment
BP GO:0016053 organic acid biosynthetic process IEP Enrichment
MF GO:0016301 kinase activity IEP Enrichment
MF GO:0016421 CoA carboxylase activity IEP Enrichment
MF GO:0016740 transferase activity IEP Enrichment
MF GO:0016741 transferase activity, transferring one-carbon groups IEP Enrichment
MF GO:0016772 transferase activity, transferring phosphorus-containing groups IEP Enrichment
MF GO:0016779 nucleotidyltransferase activity IEP Enrichment
MF GO:0016866 intramolecular transferase activity IEP Enrichment
MF GO:0016879 ligase activity, forming carbon-nitrogen bonds IEP Enrichment
MF GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor IEP Enrichment
MF GO:0016885 ligase activity, forming carbon-carbon bonds IEP Enrichment
MF GO:0017076 purine nucleotide binding IEP Enrichment
BP GO:0019359 nicotinamide nucleotide biosynthetic process IEP Enrichment
BP GO:0019362 pyridine nucleotide metabolic process IEP Enrichment
BP GO:0019363 pyridine nucleotide biosynthetic process IEP Enrichment
MF GO:0030554 adenyl nucleotide binding IEP Enrichment
MF GO:0030983 mismatched DNA binding IEP Enrichment
MF GO:0032553 ribonucleotide binding IEP Enrichment
MF GO:0032555 purine ribonucleotide binding IEP Enrichment
MF GO:0032559 adenyl ribonucleotide binding IEP Enrichment
MF GO:0035639 purine ribonucleoside triphosphate binding IEP Enrichment
MF GO:0036094 small molecule binding IEP Enrichment
BP GO:0042726 flavin-containing compound metabolic process IEP Enrichment
BP GO:0042727 flavin-containing compound biosynthetic process IEP Enrichment
MF GO:0043167 ion binding IEP Enrichment
MF GO:0043168 anion binding IEP Enrichment
BP GO:0043412 macromolecule modification IEP Enrichment
BP GO:0043648 dicarboxylic acid metabolic process IEP Enrichment
BP GO:0044255 cellular lipid metabolic process IEP Enrichment
BP GO:0044283 small molecule biosynthetic process IEP Enrichment
BP GO:0046394 carboxylic acid biosynthetic process IEP Enrichment
BP GO:0046417 chorismate metabolic process IEP Enrichment
BP GO:0046496 nicotinamide nucleotide metabolic process IEP Enrichment
BP GO:0072524 pyridine-containing compound metabolic process IEP Enrichment
BP GO:0072525 pyridine-containing compound biosynthetic process IEP Enrichment
MF GO:0097159 organic cyclic compound binding IEP Enrichment
MF GO:0097367 carbohydrate derivative binding IEP Enrichment
MF GO:1901265 nucleoside phosphate binding IEP Enrichment
MF GO:1901363 heterocyclic compound binding IEP Enrichment
InterPro domains Description Start Stop
IPR004150 NAD_DNA_ligase_OB 322 398
IPR001357 BRCT_dom 597 669
IPR041663 DisA/LigA_HHH 510 572
IPR004149 Znf_DNAligase_C4 408 434
IPR013839 DNAligase_adenylation 11 319
No external refs found!