AEA93146 (ligA, OG1RF_10459)

Aliases : ligA, OG1RF_10459

Description : NAD-dependent DNA ligase LigA [Ensembl]. Helix-hairpin-helix motif, Helix-hairpin-helix domain, BRCA1 C Terminus (BRCT) domain, NAD-dependent DNA ligase OB-fold domain, NAD-dependent DNA ligase adenylation domain, NAD-dependent DNA ligase C4 zinc finger domain [Interproscan].

Gene families : OG_02_0000445 (OrthoFinder) Phylogenetic Tree(s): OG0000445_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: AEA93146
Cluster	HCCA: Cluster_7

Target	Alias	Description	ECC score	Gene Family Method
AAK99828	spr1024, ligA	DNA ligase [Ensembl]. Helix-hairpin-helix motif,...	0.06	OrthoFinder
ADK87023	ligA, MPNE_0413	DNA ligase (NAD(+)) [Ensembl]. NAD-dependent DNA ligase...	0.03	OrthoFinder
AKP15609	ligA_2, WX61_01570	DNA ligase [Ensembl]. Helix-hairpin-helix motif, BRCA1 C...	0.04	OrthoFinder
CCG26397	No alias	DNA ligase [Ensembl]. Helix-hairpin-helix motif,...	0.05	OrthoFinder
CPD03240	lig, ERS093114_01872	DNA ligase [Ensembl]. Helix-hairpin-helix motif,...	0.05	OrthoFinder
CRP54066	ligA	DNA ligase [Ensembl]. Helix-hairpin-helix motif, BRCA1 C...	0.04	OrthoFinder

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003909	DNA ligase activity	None	Extended
MF	GO:0003911	DNA ligase (NAD+) activity	IEA	Interproscan
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006260	DNA replication	IEA	Interproscan
BP	GO:0006281	DNA repair	IEA	Interproscan
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006950	response to stress	None	Extended
BP	GO:0006974	cellular response to DNA damage stimulus	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009059	macromolecule biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016874	ligase activity	None	Extended
MF	GO:0016886	ligase activity, forming phosphoric ester bonds	None	Extended
BP	GO:0033554	cellular response to stress	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034645	cellular macromolecule biosynthetic process	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051716	cellular response to stimulus	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0140097	catalytic activity, acting on DNA	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	IEP	Enrichment
BP	GO:0001522	pseudouridine synthesis	IEP	Enrichment
MF	GO:0003690	double-stranded DNA binding	IEP	Enrichment
MF	GO:0003723	RNA binding	IEP	Enrichment
MF	GO:0003725	double-stranded RNA binding	IEP	Enrichment
MF	GO:0003919	FMN adenylyltransferase activity	IEP	Enrichment
MF	GO:0003951	NAD+ kinase activity	IEP	Enrichment
MF	GO:0003989	acetyl-CoA carboxylase activity	IEP	Enrichment
MF	GO:0004329	formate-tetrahydrofolate ligase activity	IEP	Enrichment
MF	GO:0005488	binding	IEP	Enrichment
MF	GO:0005524	ATP binding	IEP	Enrichment
BP	GO:0006298	mismatch repair	IEP	Enrichment
BP	GO:0006468	protein phosphorylation	IEP	Enrichment
BP	GO:0006741	NADP biosynthetic process	IEP	Enrichment
BP	GO:0006771	riboflavin metabolic process	IEP	Enrichment
MF	GO:0008168	methyltransferase activity	IEP	Enrichment
MF	GO:0008531	riboflavin kinase activity	IEP	Enrichment
BP	GO:0008610	lipid biosynthetic process	IEP	Enrichment
MF	GO:0008839	4-hydroxy-tetrahydrodipicolinate reductase	IEP	Enrichment
BP	GO:0009231	riboflavin biosynthetic process	IEP	Enrichment
CC	GO:0009317	acetyl-CoA carboxylase complex	IEP	Enrichment
BP	GO:0009451	RNA modification	IEP	Enrichment
MF	GO:0009982	pseudouridine synthase activity	IEP	Enrichment
BP	GO:0016053	organic acid biosynthetic process	IEP	Enrichment
MF	GO:0016301	kinase activity	IEP	Enrichment
MF	GO:0016421	CoA carboxylase activity	IEP	Enrichment
MF	GO:0016740	transferase activity	IEP	Enrichment
MF	GO:0016741	transferase activity, transferring one-carbon groups	IEP	Enrichment
MF	GO:0016772	transferase activity, transferring phosphorus-containing groups	IEP	Enrichment
MF	GO:0016779	nucleotidyltransferase activity	IEP	Enrichment
MF	GO:0016866	intramolecular transferase activity	IEP	Enrichment
MF	GO:0016879	ligase activity, forming carbon-nitrogen bonds	IEP	Enrichment
MF	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor	IEP	Enrichment
MF	GO:0016885	ligase activity, forming carbon-carbon bonds	IEP	Enrichment
MF	GO:0017076	purine nucleotide binding	IEP	Enrichment
BP	GO:0019359	nicotinamide nucleotide biosynthetic process	IEP	Enrichment
BP	GO:0019362	pyridine nucleotide metabolic process	IEP	Enrichment
BP	GO:0019363	pyridine nucleotide biosynthetic process	IEP	Enrichment
MF	GO:0030554	adenyl nucleotide binding	IEP	Enrichment
MF	GO:0030983	mismatched DNA binding	IEP	Enrichment
MF	GO:0032553	ribonucleotide binding	IEP	Enrichment
MF	GO:0032555	purine ribonucleotide binding	IEP	Enrichment
MF	GO:0032559	adenyl ribonucleotide binding	IEP	Enrichment
MF	GO:0035639	purine ribonucleoside triphosphate binding	IEP	Enrichment
MF	GO:0036094	small molecule binding	IEP	Enrichment
BP	GO:0042726	flavin-containing compound metabolic process	IEP	Enrichment
BP	GO:0042727	flavin-containing compound biosynthetic process	IEP	Enrichment
MF	GO:0043167	ion binding	IEP	Enrichment
MF	GO:0043168	anion binding	IEP	Enrichment
BP	GO:0043412	macromolecule modification	IEP	Enrichment
BP	GO:0043648	dicarboxylic acid metabolic process	IEP	Enrichment
BP	GO:0044255	cellular lipid metabolic process	IEP	Enrichment
BP	GO:0044283	small molecule biosynthetic process	IEP	Enrichment
BP	GO:0046394	carboxylic acid biosynthetic process	IEP	Enrichment
BP	GO:0046417	chorismate metabolic process	IEP	Enrichment
BP	GO:0046496	nicotinamide nucleotide metabolic process	IEP	Enrichment
BP	GO:0072524	pyridine-containing compound metabolic process	IEP	Enrichment
BP	GO:0072525	pyridine-containing compound biosynthetic process	IEP	Enrichment
MF	GO:0097159	organic cyclic compound binding	IEP	Enrichment
MF	GO:0097367	carbohydrate derivative binding	IEP	Enrichment
MF	GO:1901265	nucleoside phosphate binding	IEP	Enrichment
MF	GO:1901363	heterocyclic compound binding	IEP	Enrichment

InterPro domains	Description	Start	Stop
IPR004150	NAD_DNA_ligase_OB	322	398
IPR001357	BRCT_dom	597	669
IPR041663	DisA/LigA_HHH	510	572
IPR004149	Znf_DNAligase_C4	408	434
IPR013839	DNAligase_adenylation	11	319

External Links

No external refs found!

AEA93146 (ligA, OG1RF_10459)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation