AAC73113 (thrA, b0002)

Aliases : thrA, b0002

Description : Bifunctional aspartokinase/homoserine dehydrogenase 1 [Ensembl]. ACT domain, Homoserine dehydrogenase, Amino acid kinase family [Interproscan].

Gene families : OG_02_0000145 (OrthoFinder) Phylogenetic Tree(s): OG0000145_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: AAC73113
Cluster	HCCA: Cluster_37

Target	Alias	Description	ECC score	Gene Family Method
AAK99178	spr0374, lysC	Aspartate kinase [Ensembl]. ACT domain, Amino acid...	0.04	OrthoFinder
AAL18966	STM0002, thrA	aspartokinase I [Ensembl]. ACT domain, Homoserine...	0.3	OrthoFinder
AAL22941	STM4101, metL	aspartokinase II [Ensembl]. Homoserine dehydrogenase,...	0.26	OrthoFinder
AAL23044	STM4220, lysC	lysine sensitive aspartokinase III [Ensembl]. ACT...	0.22	OrthoFinder
AGT26473	N559_4889	aspartate kinase III [Ensembl]. Amino acid kinase family...	0.18	OrthoFinder
AKI50307	L2625_02494	aspartate kinase [Ensembl]. CASTOR,...	0.07	OrthoFinder
AKP16011	lysC, WX61_01984	Aspartokinase [Ensembl]. ACT domain, Amino acid kinase...	0.03	OrthoFinder
CPC31970	lysC, ERS093114_00024	Aspartokinase [Ensembl]. Amino acid kinase family [Interproscan].	0.03	OrthoFinder
CPC33474	lysC2, ERS093114_00089	aspartate kinase [Ensembl]. Amino acid kinase family...	0.03	OrthoFinder
CRN71514	ask	Aspartokinase [Ensembl]. ACT domain, Amino acid kinase...	0.03	OrthoFinder
EDJ90402	thrA, CGSHi22421_01632	bifunctional aspartokinase I/homeserine dehydrogenase I...	0.06	OrthoFinder
EDJ90892	CGSHi22421_03548	hypothetical protein [Ensembl]. Amino acid kinase family...	0.03	OrthoFinder
KNA50221	VCV51_030256	aspartate kinase [Ensembl]. Amino acid kinase family...	0.1	OrthoFinder
KNA53043	VCV51_033356	aspartate kinase [Ensembl]. ACT domain, Amino acid...	0.15	OrthoFinder
KNA54894	VCV51_031799	homoserine dehydrogenase [Ensembl]. Amino acid kinase...	0.13	OrthoFinder
KNA59762	VCV51_032457	aspartate kinase [Ensembl]. Amino acid kinase family...	0.03	OrthoFinder

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0005488	binding	None	Extended
BP	GO:0006082	organic acid metabolic process	None	Extended
BP	GO:0006520	cellular amino acid metabolic process	IEA	Interproscan
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016491	oxidoreductase activity	IEA	Interproscan
BP	GO:0019752	carboxylic acid metabolic process	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
BP	GO:0043436	oxoacid metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
MF	GO:0050661	NADP binding	IEA	Interproscan
BP	GO:0055114	obsolete oxidation-reduction process	IEA	Interproscan
BP	GO:0071704	organic substance metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
BP	GO:0000096	sulfur amino acid metabolic process	IEP	Enrichment
BP	GO:0000097	sulfur amino acid biosynthetic process	IEP	Enrichment
MF	GO:0003871	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity	IEP	Enrichment
MF	GO:0004055	argininosuccinate synthase activity	IEP	Enrichment
MF	GO:0004107	chorismate synthase activity	IEP	Enrichment
MF	GO:0004417	hydroxyethylthiazole kinase activity	IEP	Enrichment
MF	GO:0004455	ketol-acid reductoisomerase activity	IEP	Enrichment
MF	GO:0004478	methionine adenosyltransferase activity	IEP	Enrichment
MF	GO:0004611	phosphoenolpyruvate carboxykinase activity	IEP	Enrichment
MF	GO:0004834	tryptophan synthase activity	IEP	Enrichment
BP	GO:0006526	arginine biosynthetic process	IEP	Enrichment
BP	GO:0006536	glutamate metabolic process	IEP	Enrichment
BP	GO:0006537	glutamate biosynthetic process	IEP	Enrichment
BP	GO:0006553	lysine metabolic process	IEP	Enrichment
BP	GO:0006556	S-adenosylmethionine biosynthetic process	IEP	Enrichment
BP	GO:0006568	tryptophan metabolic process	IEP	Enrichment
BP	GO:0006586	indolalkylamine metabolic process	IEP	Enrichment
BP	GO:0006766	vitamin metabolic process	IEP	Enrichment
BP	GO:0006767	water-soluble vitamin metabolic process	IEP	Enrichment
BP	GO:0006772	thiamine metabolic process	IEP	Enrichment
BP	GO:0006790	sulfur compound metabolic process	IEP	Enrichment
BP	GO:0008652	cellular amino acid biosynthetic process	IEP	Enrichment
MF	GO:0008839	4-hydroxy-tetrahydrodipicolinate reductase	IEP	Enrichment
MF	GO:0008964	phosphoenolpyruvate carboxylase activity	IEP	Enrichment
MF	GO:0008987	quinolinate synthetase A activity	IEP	Enrichment
BP	GO:0009058	biosynthetic process	IEP	Enrichment
BP	GO:0009064	glutamine family amino acid metabolic process	IEP	Enrichment
BP	GO:0009066	aspartate family amino acid metabolic process	IEP	Enrichment
BP	GO:0009067	aspartate family amino acid biosynthetic process	IEP	Enrichment
BP	GO:0009072	aromatic amino acid family metabolic process	IEP	Enrichment
BP	GO:0009081	branched-chain amino acid metabolic process	IEP	Enrichment
BP	GO:0009082	branched-chain amino acid biosynthetic process	IEP	Enrichment
BP	GO:0009084	glutamine family amino acid biosynthetic process	IEP	Enrichment
BP	GO:0009085	lysine biosynthetic process	IEP	Enrichment
BP	GO:0009086	methionine biosynthetic process	IEP	Enrichment
BP	GO:0009089	lysine biosynthetic process via diaminopimelate	IEP	Enrichment
BP	GO:0009092	homoserine metabolic process	IEP	Enrichment
BP	GO:0009110	vitamin biosynthetic process	IEP	Enrichment
BP	GO:0009228	thiamine biosynthetic process	IEP	Enrichment
BP	GO:0009435	NAD biosynthetic process	IEP	Enrichment
MF	GO:0015293	symporter activity	IEP	Enrichment
MF	GO:0015930	glutamate synthase activity	IEP	Enrichment
BP	GO:0015977	carbon fixation	IEP	Enrichment
BP	GO:0016053	organic acid biosynthetic process	IEP	Enrichment
MF	GO:0016597	amino acid binding	IEP	Enrichment
MF	GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	IEP	Enrichment
MF	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEP	Enrichment
MF	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEP	Enrichment
MF	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	IEP	Enrichment
MF	GO:0016741	transferase activity, transferring one-carbon groups	IEP	Enrichment
MF	GO:0016743	carboxyl- or carbamoyltransferase activity	IEP	Enrichment
MF	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	IEP	Enrichment
MF	GO:0016835	carbon-oxygen lyase activity	IEP	Enrichment
MF	GO:0016838	carbon-oxygen lyase activity, acting on phosphates	IEP	Enrichment
MF	GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	IEP	Enrichment
BP	GO:0019346	transsulfuration	IEP	Enrichment
BP	GO:0019438	aromatic compound biosynthetic process	IEP	Enrichment
MF	GO:0019842	vitamin binding	IEP	Enrichment
MF	GO:0030170	pyridoxal phosphate binding	IEP	Enrichment
MF	GO:0034257	nicotinamide riboside transmembrane transporter activity	IEP	Enrichment
BP	GO:0034258	nicotinamide riboside transport	IEP	Enrichment
MF	GO:0042085	5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity	IEP	Enrichment
BP	GO:0042364	water-soluble vitamin biosynthetic process	IEP	Enrichment
BP	GO:0042430	indole-containing compound metabolic process	IEP	Enrichment
BP	GO:0042723	thiamine-containing compound metabolic process	IEP	Enrichment
BP	GO:0042724	thiamine-containing compound biosynthetic process	IEP	Enrichment
MF	GO:0043168	anion binding	IEP	Enrichment
MF	GO:0043177	organic acid binding	IEP	Enrichment
BP	GO:0043648	dicarboxylic acid metabolic process	IEP	Enrichment
BP	GO:0043650	dicarboxylic acid biosynthetic process	IEP	Enrichment
BP	GO:0044249	cellular biosynthetic process	IEP	Enrichment
BP	GO:0044272	sulfur compound biosynthetic process	IEP	Enrichment
BP	GO:0044283	small molecule biosynthetic process	IEP	Enrichment
BP	GO:0046394	carboxylic acid biosynthetic process	IEP	Enrichment
BP	GO:0046451	diaminopimelate metabolic process	IEP	Enrichment
BP	GO:0046500	S-adenosylmethionine metabolic process	IEP	Enrichment
MF	GO:0046983	protein dimerization activity	IEP	Enrichment
BP	GO:0050667	homocysteine metabolic process	IEP	Enrichment
MF	GO:0051287	NAD binding	IEP	Enrichment
MF	GO:0051536	iron-sulfur cluster binding	IEP	Enrichment
MF	GO:0051540	metal cluster binding	IEP	Enrichment
MF	GO:0070279	vitamin B6 binding	IEP	Enrichment
BP	GO:0072527	pyrimidine-containing compound metabolic process	IEP	Enrichment
BP	GO:0072528	pyrimidine-containing compound biosynthetic process	IEP	Enrichment
BP	GO:1901566	organonitrogen compound biosynthetic process	IEP	Enrichment
BP	GO:1901576	organic substance biosynthetic process	IEP	Enrichment
BP	GO:1901605	alpha-amino acid metabolic process	IEP	Enrichment
BP	GO:1901607	alpha-amino acid biosynthetic process	IEP	Enrichment

InterPro domains	Description	Start	Stop
IPR001048	Asp/Glu/Uridylate_kinase	2	284
IPR001342	HDH_cat	614	811
IPR027795	CASTOR_ACT_dom	393	453
IPR005106	Asp/hSer_DH_NAD-bd	472	605
IPR002912	ACT_dom	324	376

External Links

UniProtKB	P00561

AAC73113 (thrA, b0002)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation