CPD03240 (lig, ERS093114_01872)

Aliases : lig, ERS093114_01872

Description : DNA ligase [Ensembl]. Helix-hairpin-helix motif, Helix-hairpin-helix domain, BRCA1 C Terminus (BRCT) domain, NAD-dependent DNA ligase OB-fold domain, NAD-dependent DNA ligase adenylation domain, NAD-dependent DNA ligase C4 zinc finger domain [Interproscan].

Gene families : OG_02_0000445 (OrthoFinder) Phylogenetic Tree(s): OG0000445_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: CPD03240
Cluster	HCCA: Cluster_5

Target	Alias	Description	ECC score	Gene Family Method
AAK99828	spr1024, ligA	DNA ligase [Ensembl]. Helix-hairpin-helix motif,...	0.07	OrthoFinder
ADK87023	ligA, MPNE_0413	DNA ligase (NAD(+)) [Ensembl]. NAD-dependent DNA ligase...	0.03	OrthoFinder
AEA93146	ligA, OG1RF_10459	NAD-dependent DNA ligase LigA [Ensembl]....	0.05	OrthoFinder
AGT23252	N559_1499, LigA	NAD-dependent DNA ligase LigA [Ensembl]. NAD-dependent...	0.03	OrthoFinder
AKI49752	ligA, L2625_01894	DNA ligase, NAD-dependent [Ensembl]. NAD-dependent DNA...	0.07	OrthoFinder
AKP15609	ligA_2, WX61_01570	DNA ligase [Ensembl]. Helix-hairpin-helix motif, BRCA1 C...	0.07	OrthoFinder
CBI66370	ligA, HPB8_813	NAD-dependent DNA ligase LigA [Ensembl]. BRCA1 C...	0.02	OrthoFinder
KNA56407	VCV51_030679	DNA ligase [Ensembl]. Helix-hairpin-helix motif,...	0.03	OrthoFinder

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003909	DNA ligase activity	None	Extended
MF	GO:0003911	DNA ligase (NAD+) activity	IEA	Interproscan
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006260	DNA replication	IEA	Interproscan
BP	GO:0006281	DNA repair	IEA	Interproscan
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006950	response to stress	None	Extended
BP	GO:0006974	cellular response to DNA damage stimulus	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009059	macromolecule biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016874	ligase activity	None	Extended
MF	GO:0016886	ligase activity, forming phosphoric ester bonds	None	Extended
BP	GO:0033554	cellular response to stress	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034645	cellular macromolecule biosynthetic process	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051716	cellular response to stimulus	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0140097	catalytic activity, acting on DNA	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000049	tRNA binding	IEP	Enrichment
MF	GO:0000166	nucleotide binding	IEP	Enrichment
MF	GO:0003676	nucleic acid binding	IEP	Enrichment
MF	GO:0003677	DNA binding	IEP	Enrichment
MF	GO:0003690	double-stranded DNA binding	IEP	Enrichment
MF	GO:0003723	RNA binding	IEP	Enrichment
MF	GO:0004655	porphobilinogen synthase activity	IEP	Enrichment
MF	GO:0004764	shikimate 3-dehydrogenase (NADP+) activity	IEP	Enrichment
MF	GO:0004797	thymidine kinase activity	IEP	Enrichment
MF	GO:0004812	aminoacyl-tRNA ligase activity	IEP	Enrichment
MF	GO:0004813	alanine-tRNA ligase activity	IEP	Enrichment
MF	GO:0004826	phenylalanine-tRNA ligase activity	IEP	Enrichment
MF	GO:0005488	binding	IEP	Enrichment
MF	GO:0005524	ATP binding	IEP	Enrichment
CC	GO:0005694	chromosome	IEP	Enrichment
BP	GO:0006082	organic acid metabolic process	IEP	Enrichment
BP	GO:0006298	mismatch repair	IEP	Enrichment
BP	GO:0006305	DNA alkylation	IEP	Enrichment
BP	GO:0006306	DNA methylation	IEP	Enrichment
BP	GO:0006399	tRNA metabolic process	IEP	Enrichment
BP	GO:0006418	tRNA aminoacylation for protein translation	IEP	Enrichment
BP	GO:0006419	alanyl-tRNA aminoacylation	IEP	Enrichment
BP	GO:0006432	phenylalanyl-tRNA aminoacylation	IEP	Enrichment
BP	GO:0006464	cellular protein modification process	IEP	Enrichment
BP	GO:0006468	protein phosphorylation	IEP	Enrichment
BP	GO:0006520	cellular amino acid metabolic process	IEP	Enrichment
BP	GO:0006612	protein targeting to membrane	IEP	Enrichment
BP	GO:0006613	cotranslational protein targeting to membrane	IEP	Enrichment
BP	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	IEP	Enrichment
BP	GO:0006996	organelle organization	IEP	Enrichment
MF	GO:0008168	methyltransferase activity	IEP	Enrichment
MF	GO:0008170	N-methyltransferase activity	IEP	Enrichment
MF	GO:0008963	phospho-N-acetylmuramoyl-pentapeptide-transferase activity	IEP	Enrichment
BP	GO:0016070	RNA metabolic process	IEP	Enrichment
MF	GO:0016740	transferase activity	IEP	Enrichment
MF	GO:0016741	transferase activity, transferring one-carbon groups	IEP	Enrichment
MF	GO:0016875	ligase activity, forming carbon-oxygen bonds	IEP	Enrichment
MF	GO:0017076	purine nucleotide binding	IEP	Enrichment
MF	GO:0019136	deoxynucleoside kinase activity	IEP	Enrichment
MF	GO:0019206	nucleoside kinase activity	IEP	Enrichment
BP	GO:0019752	carboxylic acid metabolic process	IEP	Enrichment
MF	GO:0030554	adenyl nucleotide binding	IEP	Enrichment
MF	GO:0030983	mismatched DNA binding	IEP	Enrichment
MF	GO:0032553	ribonucleotide binding	IEP	Enrichment
MF	GO:0032555	purine ribonucleotide binding	IEP	Enrichment
MF	GO:0032559	adenyl ribonucleotide binding	IEP	Enrichment
BP	GO:0033365	protein localization to organelle	IEP	Enrichment
BP	GO:0034613	cellular protein localization	IEP	Enrichment
BP	GO:0034660	ncRNA metabolic process	IEP	Enrichment
MF	GO:0035639	purine ribonucleoside triphosphate binding	IEP	Enrichment
MF	GO:0036094	small molecule binding	IEP	Enrichment
BP	GO:0036211	protein modification process	IEP	Enrichment
BP	GO:0043038	amino acid activation	IEP	Enrichment
BP	GO:0043039	tRNA aminoacylation	IEP	Enrichment
MF	GO:0043167	ion binding	IEP	Enrichment
MF	GO:0043168	anion binding	IEP	Enrichment
BP	GO:0043412	macromolecule modification	IEP	Enrichment
BP	GO:0043436	oxoacid metabolic process	IEP	Enrichment
BP	GO:0044281	small molecule metabolic process	IEP	Enrichment
BP	GO:0044728	DNA methylation or demethylation	IEP	Enrichment
BP	GO:0045047	protein targeting to ER	IEP	Enrichment
BP	GO:0051276	chromosome organization	IEP	Enrichment
BP	GO:0051668	localization within membrane	IEP	Enrichment
BP	GO:0070727	cellular macromolecule localization	IEP	Enrichment
BP	GO:0070972	protein localization to endoplasmic reticulum	IEP	Enrichment
MF	GO:0071949	FAD binding	IEP	Enrichment
BP	GO:0072594	establishment of protein localization to organelle	IEP	Enrichment
BP	GO:0072599	establishment of protein localization to endoplasmic reticulum	IEP	Enrichment
BP	GO:0072657	protein localization to membrane	IEP	Enrichment
BP	GO:0090150	establishment of protein localization to membrane	IEP	Enrichment
MF	GO:0097159	organic cyclic compound binding	IEP	Enrichment
MF	GO:0097367	carbohydrate derivative binding	IEP	Enrichment
MF	GO:0140098	catalytic activity, acting on RNA	IEP	Enrichment
MF	GO:0140101	catalytic activity, acting on a tRNA	IEP	Enrichment
MF	GO:1901265	nucleoside phosphate binding	IEP	Enrichment
MF	GO:1901363	heterocyclic compound binding	IEP	Enrichment
BP	GO:1901564	organonitrogen compound metabolic process	IEP	Enrichment

InterPro domains	Description	Start	Stop
IPR004149	Znf_DNAligase_C4	400	426
IPR013839	DNAligase_adenylation	5	311
IPR041663	DisA/LigA_HHH	503	565
IPR004150	NAD_DNA_ligase_OB	315	391
IPR001357	BRCT_dom	591	660

External Links

No external refs found!

CPD03240 (lig, ERS093114_01872)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation