AAK99828 (spr1024, ligA)

Aliases : spr1024, ligA

Description : DNA ligase [Ensembl]. Helix-hairpin-helix motif, Helix-hairpin-helix domain, BRCA1 C Terminus (BRCT) domain, NAD-dependent DNA ligase OB-fold domain, NAD-dependent DNA ligase adenylation domain, NAD-dependent DNA ligase C4 zinc finger domain [Interproscan].

Gene families : OG_02_0000445 (OrthoFinder) Phylogenetic Tree(s): OG0000445_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: AAK99828
Cluster	HCCA: Cluster_18

Target	Alias	Description	ECC score	Gene Family Method
ADK87023	ligA, MPNE_0413	DNA ligase (NAD(+)) [Ensembl]. NAD-dependent DNA ligase...	0.03	OrthoFinder
AEA93146	ligA, OG1RF_10459	NAD-dependent DNA ligase LigA [Ensembl]....	0.06	OrthoFinder
AGT23252	N559_1499, LigA	NAD-dependent DNA ligase LigA [Ensembl]. NAD-dependent...	0.03	OrthoFinder
AHY39823	ligA, CJ8421_02860	NAD-dependent DNA ligase LigA [Ensembl]....	0.04	OrthoFinder
AKI49752	ligA, L2625_01894	DNA ligase, NAD-dependent [Ensembl]. NAD-dependent DNA...	0.05	OrthoFinder
AKP15609	ligA_2, WX61_01570	DNA ligase [Ensembl]. Helix-hairpin-helix motif, BRCA1 C...	0.07	OrthoFinder
CCG26397	No alias	DNA ligase [Ensembl]. Helix-hairpin-helix motif,...	0.06	OrthoFinder
CPD03240	lig, ERS093114_01872	DNA ligase [Ensembl]. Helix-hairpin-helix motif,...	0.07	OrthoFinder
CRP54066	ligA	DNA ligase [Ensembl]. Helix-hairpin-helix motif, BRCA1 C...	0.03	OrthoFinder
KNA56407	VCV51_030679	DNA ligase [Ensembl]. Helix-hairpin-helix motif,...	0.03	OrthoFinder

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003909	DNA ligase activity	None	Extended
MF	GO:0003911	DNA ligase (NAD+) activity	IEA	Interproscan
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006260	DNA replication	IEA	Interproscan
BP	GO:0006281	DNA repair	IEA	Interproscan
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006950	response to stress	None	Extended
BP	GO:0006974	cellular response to DNA damage stimulus	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009059	macromolecule biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0016874	ligase activity	None	Extended
MF	GO:0016886	ligase activity, forming phosphoric ester bonds	None	Extended
BP	GO:0033554	cellular response to stress	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034645	cellular macromolecule biosynthetic process	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051716	cellular response to stimulus	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0140097	catalytic activity, acting on DNA	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	IEP	Enrichment
MF	GO:0000287	magnesium ion binding	IEP	Enrichment
BP	GO:0000921	septin ring assembly	IEP	Enrichment
MF	GO:0003924	GTPase activity	IEP	Enrichment
MF	GO:0004347	glucose-6-phosphate isomerase activity	IEP	Enrichment
MF	GO:0004812	aminoacyl-tRNA ligase activity	IEP	Enrichment
MF	GO:0004813	alanine-tRNA ligase activity	IEP	Enrichment
MF	GO:0004820	glycine-tRNA ligase activity	IEP	Enrichment
MF	GO:0004832	valine-tRNA ligase activity	IEP	Enrichment
MF	GO:0005488	binding	IEP	Enrichment
MF	GO:0005524	ATP binding	IEP	Enrichment
MF	GO:0005525	GTP binding	IEP	Enrichment
CC	GO:0005737	cytoplasm	IEP	Enrichment
CC	GO:0005856	cytoskeleton	IEP	Enrichment
CC	GO:0005940	septin ring	IEP	Enrichment
BP	GO:0005975	carbohydrate metabolic process	IEP	Enrichment
BP	GO:0006066	alcohol metabolic process	IEP	Enrichment
BP	GO:0006082	organic acid metabolic process	IEP	Enrichment
BP	GO:0006399	tRNA metabolic process	IEP	Enrichment
BP	GO:0006520	cellular amino acid metabolic process	IEP	Enrichment
BP	GO:0006605	protein targeting	IEP	Enrichment
BP	GO:0006612	protein targeting to membrane	IEP	Enrichment
BP	GO:0006613	cotranslational protein targeting to membrane	IEP	Enrichment
BP	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	IEP	Enrichment
BP	GO:0006886	intracellular protein transport	IEP	Enrichment
BP	GO:0007010	cytoskeleton organization	IEP	Enrichment
BP	GO:0007165	signal transduction	IEP	Enrichment
BP	GO:0008104	protein localization	IEP	Enrichment
MF	GO:0008312	7S RNA binding	IEP	Enrichment
MF	GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	IEP	Enrichment
BP	GO:0015031	protein transport	IEP	Enrichment
MF	GO:0016462	pyrophosphatase activity	IEP	Enrichment
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	IEP	Enrichment
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEP	Enrichment
MF	GO:0016875	ligase activity, forming carbon-oxygen bonds	IEP	Enrichment
MF	GO:0017076	purine nucleotide binding	IEP	Enrichment
MF	GO:0017111	nucleoside-triphosphatase activity	IEP	Enrichment
MF	GO:0019001	guanyl nucleotide binding	IEP	Enrichment
BP	GO:0019752	carboxylic acid metabolic process	IEP	Enrichment
MF	GO:0030554	adenyl nucleotide binding	IEP	Enrichment
BP	GO:0031106	septin ring organization	IEP	Enrichment
MF	GO:0031406	carboxylic acid binding	IEP	Enrichment
CC	GO:0032156	septin cytoskeleton	IEP	Enrichment
BP	GO:0032185	septin cytoskeleton organization	IEP	Enrichment
MF	GO:0032553	ribonucleotide binding	IEP	Enrichment
MF	GO:0032555	purine ribonucleotide binding	IEP	Enrichment
MF	GO:0032559	adenyl ribonucleotide binding	IEP	Enrichment
MF	GO:0032561	guanyl ribonucleotide binding	IEP	Enrichment
BP	GO:0033036	macromolecule localization	IEP	Enrichment
BP	GO:0033365	protein localization to organelle	IEP	Enrichment
BP	GO:0034613	cellular protein localization	IEP	Enrichment
BP	GO:0034660	ncRNA metabolic process	IEP	Enrichment
MF	GO:0035639	purine ribonucleoside triphosphate binding	IEP	Enrichment
MF	GO:0036094	small molecule binding	IEP	Enrichment
BP	GO:0042180	cellular ketone metabolic process	IEP	Enrichment
BP	GO:0042181	ketone biosynthetic process	IEP	Enrichment
BP	GO:0043038	amino acid activation	IEP	Enrichment
BP	GO:0043039	tRNA aminoacylation	IEP	Enrichment
MF	GO:0043167	ion binding	IEP	Enrichment
MF	GO:0043168	anion binding	IEP	Enrichment
MF	GO:0043169	cation binding	IEP	Enrichment
MF	GO:0043177	organic acid binding	IEP	Enrichment
BP	GO:0043436	oxoacid metabolic process	IEP	Enrichment
BP	GO:0044281	small molecule metabolic process	IEP	Enrichment
BP	GO:0045047	protein targeting to ER	IEP	Enrichment
BP	GO:0045149	acetoin metabolic process	IEP	Enrichment
BP	GO:0045151	acetoin biosynthetic process	IEP	Enrichment
BP	GO:0045184	establishment of protein localization	IEP	Enrichment
BP	GO:0046165	alcohol biosynthetic process	IEP	Enrichment
BP	GO:0046907	intracellular transport	IEP	Enrichment
CC	GO:0048500	signal recognition particle	IEP	Enrichment
BP	GO:0051641	cellular localization	IEP	Enrichment
BP	GO:0051649	establishment of localization in cell	IEP	Enrichment
BP	GO:0051668	localization within membrane	IEP	Enrichment
BP	GO:0070727	cellular macromolecule localization	IEP	Enrichment
BP	GO:0070925	organelle assembly	IEP	Enrichment
BP	GO:0070972	protein localization to endoplasmic reticulum	IEP	Enrichment
BP	GO:0072594	establishment of protein localization to organelle	IEP	Enrichment
BP	GO:0072599	establishment of protein localization to endoplasmic reticulum	IEP	Enrichment
BP	GO:0072657	protein localization to membrane	IEP	Enrichment
BP	GO:0090150	establishment of protein localization to membrane	IEP	Enrichment
MF	GO:0097159	organic cyclic compound binding	IEP	Enrichment
MF	GO:0097367	carbohydrate derivative binding	IEP	Enrichment
MF	GO:0140098	catalytic activity, acting on RNA	IEP	Enrichment
MF	GO:0140101	catalytic activity, acting on a tRNA	IEP	Enrichment
MF	GO:1901265	nucleoside phosphate binding	IEP	Enrichment
MF	GO:1901363	heterocyclic compound binding	IEP	Enrichment
BP	GO:1901615	organic hydroxy compound metabolic process	IEP	Enrichment
BP	GO:1901617	organic hydroxy compound biosynthetic process	IEP	Enrichment
MF	GO:1901681	sulfur compound binding	IEP	Enrichment
BP	GO:1902652	secondary alcohol metabolic process	IEP	Enrichment
BP	GO:1902653	secondary alcohol biosynthetic process	IEP	Enrichment
CC	GO:1990904	ribonucleoprotein complex	IEP	Enrichment

InterPro domains	Description	Start	Stop
IPR013839	DNAligase_adenylation	2	306
IPR004149	Znf_DNAligase_C4	394	420
IPR004150	NAD_DNA_ligase_OB	310	385
IPR041663	DisA/LigA_HHH	496	554
IPR001357	BRCT_dom	582	650

External Links

No external refs found!

AAK99828 (spr1024, ligA)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation