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  5. AAC73631

AAC73631 (folD, b0529)


Aliases : folD, b0529

Description : bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase [Ensembl]. Tetrahydrofolate dehydrogenase/cyclohydrolase [Interproscan].


Gene families : OG_02_0000724 (OrthoFinder) Phylogenetic Tree(s): OG0000724_tree

Sequence : coding (download), protein (download)


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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: AAC73631
Cluster HCCA: Cluster_41

Target Alias Description ECC score Gene Family Method Actions
AAL19496 STM0542, folD 5,10-methylene-tetrahydrofolate dehydrogenase [Ensembl].... 0.17 OrthoFinder
AHY40078 CJ8421_04255 bifunctional 5,10-methylene-tetrahydrofolate... 0.03 OrthoFinder
AKP14964 folD, WX61_00901 Bifunctional protein FolD protein [Ensembl].... 0.03 OrthoFinder
CPC41101 folD, ERS093114_00361 Methenyltetrahydrofolate cyclohydrolase [Ensembl].... 0.08 OrthoFinder
CRP57553 folD Bifunctional protein FolD protein [Ensembl].... 0.09 OrthoFinder
EDJ90266 CGSHi22421_06484 FolD bifunctional protein [Ensembl]. Tetrahydrofolate... 0.06 OrthoFinder

Type GO Term Name Evidence Source
MF GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA Interproscan
BP GO:0055114 obsolete oxidation-reduction process IEA Interproscan
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Type GO Term Name Evidence Source
MF GO:0000166 nucleotide binding IEP Enrichment
MF GO:0000287 magnesium ion binding IEP Enrichment
MF GO:0002161 aminoacyl-tRNA editing activity IEP Enrichment
MF GO:0003676 nucleic acid binding IEP Enrichment
MF GO:0003723 RNA binding IEP Enrichment
MF GO:0003937 IMP cyclohydrolase activity IEP Enrichment
MF GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity IEP Enrichment
MF GO:0004107 chorismate synthase activity IEP Enrichment
MF GO:0004427 inorganic diphosphatase activity IEP Enrichment
MF GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity IEP Enrichment
MF GO:0004592 pantoate-beta-alanine ligase activity IEP Enrichment
MF GO:0004637 phosphoribosylamine-glycine ligase activity IEP Enrichment
MF GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity IEP Enrichment
MF GO:0004749 ribose phosphate diphosphokinase activity IEP Enrichment
MF GO:0004812 aminoacyl-tRNA ligase activity IEP Enrichment
MF GO:0004817 cysteine-tRNA ligase activity IEP Enrichment
MF GO:0004820 glycine-tRNA ligase activity IEP Enrichment
MF GO:0004832 valine-tRNA ligase activity IEP Enrichment
MF GO:0005488 binding IEP Enrichment
MF GO:0005524 ATP binding IEP Enrichment
MF GO:0005539 glycosaminoglycan binding IEP Enrichment
CC GO:0005737 cytoplasm IEP Enrichment
BP GO:0006082 organic acid metabolic process IEP Enrichment
BP GO:0006139 nucleobase-containing compound metabolic process IEP Enrichment
BP GO:0006144 purine nucleobase metabolic process IEP Enrichment
BP GO:0006163 purine nucleotide metabolic process IEP Enrichment
BP GO:0006164 purine nucleotide biosynthetic process IEP Enrichment
BP GO:0006188 IMP biosynthetic process IEP Enrichment
BP GO:0006189 'de novo' IMP biosynthetic process IEP Enrichment
BP GO:0006308 DNA catabolic process IEP Enrichment
BP GO:0006399 tRNA metabolic process IEP Enrichment
BP GO:0006418 tRNA aminoacylation for protein translation IEP Enrichment
BP GO:0006423 cysteinyl-tRNA aminoacylation IEP Enrichment
BP GO:0006426 glycyl-tRNA aminoacylation IEP Enrichment
BP GO:0006438 valyl-tRNA aminoacylation IEP Enrichment
BP GO:0006520 cellular amino acid metabolic process IEP Enrichment
BP GO:0006725 cellular aromatic compound metabolic process IEP Enrichment
BP GO:0006753 nucleoside phosphate metabolic process IEP Enrichment
BP GO:0006793 phosphorus metabolic process IEP Enrichment
BP GO:0006796 phosphate-containing compound metabolic process IEP Enrichment
BP GO:0006807 nitrogen compound metabolic process IEP Enrichment
BP GO:0008150 biological_process IEP Enrichment
BP GO:0008152 metabolic process IEP Enrichment
MF GO:0008855 exodeoxyribonuclease VII activity IEP Enrichment
BP GO:0009058 biosynthetic process IEP Enrichment
BP GO:0009113 purine nucleobase biosynthetic process IEP Enrichment
BP GO:0009116 nucleoside metabolic process IEP Enrichment
BP GO:0009117 nucleotide metabolic process IEP Enrichment
BP GO:0009123 nucleoside monophosphate metabolic process IEP Enrichment
BP GO:0009124 nucleoside monophosphate biosynthetic process IEP Enrichment
BP GO:0009126 purine nucleoside monophosphate metabolic process IEP Enrichment
BP GO:0009127 purine nucleoside monophosphate biosynthetic process IEP Enrichment
BP GO:0009150 purine ribonucleotide metabolic process IEP Enrichment
BP GO:0009152 purine ribonucleotide biosynthetic process IEP Enrichment
BP GO:0009156 ribonucleoside monophosphate biosynthetic process IEP Enrichment
BP GO:0009161 ribonucleoside monophosphate metabolic process IEP Enrichment
BP GO:0009165 nucleotide biosynthetic process IEP Enrichment
BP GO:0009167 purine ribonucleoside monophosphate metabolic process IEP Enrichment
BP GO:0009168 purine ribonucleoside monophosphate biosynthetic process IEP Enrichment
BP GO:0009259 ribonucleotide metabolic process IEP Enrichment
BP GO:0009260 ribonucleotide biosynthetic process IEP Enrichment
CC GO:0009279 cell outer membrane IEP Enrichment
CC GO:0009318 exodeoxyribonuclease VII complex IEP Enrichment
BP GO:0009435 NAD biosynthetic process IEP Enrichment
BP GO:0009987 cellular process IEP Enrichment
BP GO:0015939 pantothenate metabolic process IEP Enrichment
BP GO:0015940 pantothenate biosynthetic process IEP Enrichment
BP GO:0016070 RNA metabolic process IEP Enrichment
MF GO:0016742 hydroxymethyl-, formyl- and related transferase activity IEP Enrichment
MF GO:0016778 diphosphotransferase activity IEP Enrichment
MF GO:0016788 hydrolase activity, acting on ester bonds IEP Enrichment
MF GO:0016838 carbon-oxygen lyase activity, acting on phosphates IEP Enrichment
MF GO:0016874 ligase activity IEP Enrichment
MF GO:0016875 ligase activity, forming carbon-oxygen bonds IEP Enrichment
MF GO:0016879 ligase activity, forming carbon-nitrogen bonds IEP Enrichment
MF GO:0017076 purine nucleotide binding IEP Enrichment
BP GO:0018130 heterocycle biosynthetic process IEP Enrichment
MF GO:0019238 cyclohydrolase activity IEP Enrichment
BP GO:0019438 aromatic compound biosynthetic process IEP Enrichment
BP GO:0019637 organophosphate metabolic process IEP Enrichment
BP GO:0019693 ribose phosphate metabolic process IEP Enrichment
BP GO:0019752 carboxylic acid metabolic process IEP Enrichment
MF GO:0030554 adenyl nucleotide binding IEP Enrichment
MF GO:0032553 ribonucleotide binding IEP Enrichment
MF GO:0032555 purine ribonucleotide binding IEP Enrichment
MF GO:0032559 adenyl ribonucleotide binding IEP Enrichment
BP GO:0034641 cellular nitrogen compound metabolic process IEP Enrichment
BP GO:0034654 nucleobase-containing compound biosynthetic process IEP Enrichment
BP GO:0034660 ncRNA metabolic process IEP Enrichment
MF GO:0035596 methylthiotransferase activity IEP Enrichment
MF GO:0035639 purine ribonucleoside triphosphate binding IEP Enrichment
MF GO:0036094 small molecule binding IEP Enrichment
BP GO:0042440 pigment metabolic process IEP Enrichment
MF GO:0042834 peptidoglycan binding IEP Enrichment
BP GO:0043038 amino acid activation IEP Enrichment
BP GO:0043039 tRNA aminoacylation IEP Enrichment
MF GO:0043167 ion binding IEP Enrichment
MF GO:0043168 anion binding IEP Enrichment
BP GO:0043170 macromolecule metabolic process IEP Enrichment
BP GO:0043436 oxoacid metabolic process IEP Enrichment
BP GO:0044237 cellular metabolic process IEP Enrichment
BP GO:0044238 primary metabolic process IEP Enrichment
BP GO:0044249 cellular biosynthetic process IEP Enrichment
BP GO:0044271 cellular nitrogen compound biosynthetic process IEP Enrichment
BP GO:0044281 small molecule metabolic process IEP Enrichment
BP GO:0046040 IMP metabolic process IEP Enrichment
BP GO:0046148 pigment biosynthetic process IEP Enrichment
BP GO:0046390 ribose phosphate biosynthetic process IEP Enrichment
BP GO:0046483 heterocycle metabolic process IEP Enrichment
MF GO:0050497 alkylthioltransferase activity IEP Enrichment
MF GO:0052689 carboxylic ester hydrolase activity IEP Enrichment
BP GO:0055086 nucleobase-containing small molecule metabolic process IEP Enrichment
BP GO:0071704 organic substance metabolic process IEP Enrichment
BP GO:0072521 purine-containing compound metabolic process IEP Enrichment
BP GO:0072522 purine-containing compound biosynthetic process IEP Enrichment
BP GO:0090304 nucleic acid metabolic process IEP Enrichment
BP GO:0090407 organophosphate biosynthetic process IEP Enrichment
MF GO:0097159 organic cyclic compound binding IEP Enrichment
MF GO:0097367 carbohydrate derivative binding IEP Enrichment
MF GO:0140098 catalytic activity, acting on RNA IEP Enrichment
MF GO:0140101 catalytic activity, acting on a tRNA IEP Enrichment
BP GO:1901135 carbohydrate derivative metabolic process IEP Enrichment
MF GO:1901265 nucleoside phosphate binding IEP Enrichment
BP GO:1901293 nucleoside phosphate biosynthetic process IEP Enrichment
BP GO:1901360 organic cyclic compound metabolic process IEP Enrichment
BP GO:1901362 organic cyclic compound biosynthetic process IEP Enrichment
MF GO:1901363 heterocyclic compound binding IEP Enrichment
BP GO:1901564 organonitrogen compound metabolic process IEP Enrichment
BP GO:1901566 organonitrogen compound biosynthetic process IEP Enrichment
BP GO:1901576 organic substance biosynthetic process IEP Enrichment
BP GO:1901657 glycosyl compound metabolic process IEP Enrichment
InterPro domains Description Start Stop
IPR020631 THF_DH/CycHdrlase_NAD-bd_dom 124 279
IPR020630 THF_DH/CycHdrlase_cat_dom 5 121
UniProtKB P24186