AAL19496 (STM0542, folD)

Aliases : STM0542, folD

Description : 5,10-methylene-tetrahydrofolate dehydrogenase [Ensembl]. Tetrahydrofolate dehydrogenase/cyclohydrolase [Interproscan].

Gene families : OG_02_0000724 (OrthoFinder) Phylogenetic Tree(s): OG0000724_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: AAL19496
Cluster	HCCA: Cluster_31

Target	Alias	Description	ECC score	Gene Family Method
AAC73631	folD, b0529	bifunctional 5,10-methylene-tetrahydrofolate...	0.17	OrthoFinder
AEA93399	folD, OG1RF_10712	bifunctional methylenetetrahydrofolate...	0.03	OrthoFinder
AHY40078	CJ8421_04255	bifunctional 5,10-methylene-tetrahydrofolate...	0.03	OrthoFinder
CCG26394	No alias	Methylenetetrahydrofolate dehydrogenase (NADP+) /...	0.02	OrthoFinder
CPC41101	folD, ERS093114_00361	Methenyltetrahydrofolate cyclohydrolase [Ensembl]....	0.04	OrthoFinder
CRP57553	folD	Bifunctional protein FolD protein [Ensembl]....	0.07	OrthoFinder
EDJ90266	CGSHi22421_06484	FolD bifunctional protein [Ensembl]. Tetrahydrofolate...	0.04	OrthoFinder

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004486	methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity	None	Extended
MF	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	IEA	Interproscan
MF	GO:0016491	oxidoreductase activity	None	Extended
MF	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	None	Extended
MF	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	None	Extended
BP	GO:0055114	obsolete oxidation-reduction process	IEA	Interproscan

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Type	GO Term	Name	Evidence	Source
BP	GO:0000154	rRNA modification	IEP	Enrichment
MF	GO:0000166	nucleotide binding	IEP	Enrichment
BP	GO:0001510	RNA methylation	IEP	Enrichment
MF	GO:0002161	aminoacyl-tRNA editing activity	IEP	Enrichment
MF	GO:0003676	nucleic acid binding	IEP	Enrichment
MF	GO:0003723	RNA binding	IEP	Enrichment
MF	GO:0003887	DNA-directed DNA polymerase activity	IEP	Enrichment
MF	GO:0003916	DNA topoisomerase activity	IEP	Enrichment
MF	GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IEP	Enrichment
MF	GO:0003919	FMN adenylyltransferase activity	IEP	Enrichment
MF	GO:0004107	chorismate synthase activity	IEP	Enrichment
MF	GO:0004611	phosphoenolpyruvate carboxykinase activity	IEP	Enrichment
MF	GO:0004812	aminoacyl-tRNA ligase activity	IEP	Enrichment
MF	GO:0004814	arginine-tRNA ligase activity	IEP	Enrichment
MF	GO:0004820	glycine-tRNA ligase activity	IEP	Enrichment
MF	GO:0004832	valine-tRNA ligase activity	IEP	Enrichment
MF	GO:0005488	binding	IEP	Enrichment
MF	GO:0005524	ATP binding	IEP	Enrichment
CC	GO:0005737	cytoplasm	IEP	Enrichment
BP	GO:0006082	organic acid metabolic process	IEP	Enrichment
BP	GO:0006139	nucleobase-containing compound metabolic process	IEP	Enrichment
BP	GO:0006188	IMP biosynthetic process	IEP	Enrichment
BP	GO:0006189	'de novo' IMP biosynthetic process	IEP	Enrichment
BP	GO:0006259	DNA metabolic process	IEP	Enrichment
BP	GO:0006265	DNA topological change	IEP	Enrichment
BP	GO:0006364	rRNA processing	IEP	Enrichment
BP	GO:0006396	RNA processing	IEP	Enrichment
BP	GO:0006399	tRNA metabolic process	IEP	Enrichment
BP	GO:0006418	tRNA aminoacylation for protein translation	IEP	Enrichment
BP	GO:0006420	arginyl-tRNA aminoacylation	IEP	Enrichment
BP	GO:0006426	glycyl-tRNA aminoacylation	IEP	Enrichment
BP	GO:0006438	valyl-tRNA aminoacylation	IEP	Enrichment
BP	GO:0006520	cellular amino acid metabolic process	IEP	Enrichment
BP	GO:0006720	isoprenoid metabolic process	IEP	Enrichment
BP	GO:0006725	cellular aromatic compound metabolic process	IEP	Enrichment
BP	GO:0006753	nucleoside phosphate metabolic process	IEP	Enrichment
BP	GO:0006793	phosphorus metabolic process	IEP	Enrichment
BP	GO:0006796	phosphate-containing compound metabolic process	IEP	Enrichment
BP	GO:0006807	nitrogen compound metabolic process	IEP	Enrichment
BP	GO:0006996	organelle organization	IEP	Enrichment
MF	GO:0008094	ATPase, acting on DNA	IEP	Enrichment
BP	GO:0008150	biological_process	IEP	Enrichment
BP	GO:0008152	metabolic process	IEP	Enrichment
MF	GO:0008171	O-methyltransferase activity	IEP	Enrichment
MF	GO:0008173	RNA methyltransferase activity	IEP	Enrichment
MF	GO:0008175	tRNA methyltransferase activity	IEP	Enrichment
BP	GO:0008299	isoprenoid biosynthetic process	IEP	Enrichment
MF	GO:0008531	riboflavin kinase activity	IEP	Enrichment
MF	GO:0008705	methionine synthase activity	IEP	Enrichment
MF	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	IEP	Enrichment
MF	GO:0008964	phosphoenolpyruvate carboxylase activity	IEP	Enrichment
MF	GO:0009020	tRNA (guanosine-2'-O-)-methyltransferase activity	IEP	Enrichment
BP	GO:0009058	biosynthetic process	IEP	Enrichment
BP	GO:0009086	methionine biosynthetic process	IEP	Enrichment
BP	GO:0009143	nucleoside triphosphate catabolic process	IEP	Enrichment
BP	GO:0009403	toxin biosynthetic process	IEP	Enrichment
BP	GO:0009404	toxin metabolic process	IEP	Enrichment
BP	GO:0009987	cellular process	IEP	Enrichment
BP	GO:0015969	guanosine tetraphosphate metabolic process	IEP	Enrichment
BP	GO:0015977	carbon fixation	IEP	Enrichment
BP	GO:0016070	RNA metabolic process	IEP	Enrichment
BP	GO:0016072	rRNA metabolic process	IEP	Enrichment
MF	GO:0016423	tRNA (guanine) methyltransferase activity	IEP	Enrichment
MF	GO:0016740	transferase activity	IEP	Enrichment
MF	GO:0016741	transferase activity, transferring one-carbon groups	IEP	Enrichment
MF	GO:0016779	nucleotidyltransferase activity	IEP	Enrichment
MF	GO:0016838	carbon-oxygen lyase activity, acting on phosphates	IEP	Enrichment
MF	GO:0016874	ligase activity	IEP	Enrichment
MF	GO:0016875	ligase activity, forming carbon-oxygen bonds	IEP	Enrichment
MF	GO:0016887	ATPase	IEP	Enrichment
MF	GO:0017076	purine nucleotide binding	IEP	Enrichment
BP	GO:0019748	secondary metabolic process	IEP	Enrichment
BP	GO:0019752	carboxylic acid metabolic process	IEP	Enrichment
MF	GO:0030554	adenyl nucleotide binding	IEP	Enrichment
BP	GO:0031167	rRNA methylation	IEP	Enrichment
MF	GO:0031419	cobalamin binding	IEP	Enrichment
MF	GO:0032553	ribonucleotide binding	IEP	Enrichment
MF	GO:0032555	purine ribonucleotide binding	IEP	Enrichment
MF	GO:0032559	adenyl ribonucleotide binding	IEP	Enrichment
BP	GO:0034035	purine ribonucleoside bisphosphate metabolic process	IEP	Enrichment
MF	GO:0034061	DNA polymerase activity	IEP	Enrichment
BP	GO:0034470	ncRNA processing	IEP	Enrichment
BP	GO:0034641	cellular nitrogen compound metabolic process	IEP	Enrichment
BP	GO:0034660	ncRNA metabolic process	IEP	Enrichment
MF	GO:0035639	purine ribonucleoside triphosphate binding	IEP	Enrichment
MF	GO:0036094	small molecule binding	IEP	Enrichment
MF	GO:0042084	5-methyltetrahydrofolate-dependent methyltransferase activity	IEP	Enrichment
BP	GO:0043038	amino acid activation	IEP	Enrichment
BP	GO:0043039	tRNA aminoacylation	IEP	Enrichment
MF	GO:0043167	ion binding	IEP	Enrichment
MF	GO:0043168	anion binding	IEP	Enrichment
BP	GO:0043170	macromolecule metabolic process	IEP	Enrichment
BP	GO:0043436	oxoacid metabolic process	IEP	Enrichment
BP	GO:0044237	cellular metabolic process	IEP	Enrichment
BP	GO:0044238	primary metabolic process	IEP	Enrichment
BP	GO:0044249	cellular biosynthetic process	IEP	Enrichment
BP	GO:0044260	cellular macromolecule metabolic process	IEP	Enrichment
BP	GO:0044281	small molecule metabolic process	IEP	Enrichment
BP	GO:0044283	small molecule biosynthetic process	IEP	Enrichment
BP	GO:0044550	secondary metabolite biosynthetic process	IEP	Enrichment
BP	GO:0046040	IMP metabolic process	IEP	Enrichment
BP	GO:0046483	heterocycle metabolic process	IEP	Enrichment
MF	GO:0050660	flavin adenine dinucleotide binding	IEP	Enrichment
BP	GO:0051276	chromosome organization	IEP	Enrichment
MF	GO:0052689	carboxylic ester hydrolase activity	IEP	Enrichment
BP	GO:0055086	nucleobase-containing small molecule metabolic process	IEP	Enrichment
MF	GO:0062105	RNA 2'-O-methyltransferase activity	IEP	Enrichment
BP	GO:0070475	rRNA base methylation	IEP	Enrichment
BP	GO:0071103	DNA conformation change	IEP	Enrichment
BP	GO:0071704	organic substance metabolic process	IEP	Enrichment
BP	GO:0090304	nucleic acid metabolic process	IEP	Enrichment
MF	GO:0097159	organic cyclic compound binding	IEP	Enrichment
MF	GO:0097367	carbohydrate derivative binding	IEP	Enrichment
MF	GO:0106050	tRNA 2'-O-methyltransferase activity	IEP	Enrichment
MF	GO:0140097	catalytic activity, acting on DNA	IEP	Enrichment
MF	GO:0140098	catalytic activity, acting on RNA	IEP	Enrichment
MF	GO:0140101	catalytic activity, acting on a tRNA	IEP	Enrichment
MF	GO:1901265	nucleoside phosphate binding	IEP	Enrichment
BP	GO:1901360	organic cyclic compound metabolic process	IEP	Enrichment
MF	GO:1901363	heterocyclic compound binding	IEP	Enrichment
BP	GO:1901564	organonitrogen compound metabolic process	IEP	Enrichment
BP	GO:1901576	organic substance biosynthetic process	IEP	Enrichment

InterPro domains	Description	Start	Stop
IPR020630	THF_DH/CycHdrlase_cat_dom	5	121
IPR020631	THF_DH/CycHdrlase_NAD-bd_dom	124	279

External Links

No external refs found!

AAL19496 (STM0542, folD)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation