CPC34369 (mutL, ERS093114_00128)

Aliases : mutL, ERS093114_00128

Description : DNA mismatch repair protein MutL [Ensembl]. Histidine kinase-, DNA mismatch repair protein, MutL C terminal dimerisation domain [Interproscan].

Gene families : OG_02_0000756 (OrthoFinder) Phylogenetic Tree(s): OG0000756_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: CPC34369
Cluster	HCCA: Cluster_5

Target	Alias	Description	ECC score	Gene Family Method
AEA95121	hexB, OG1RF_12434	DNA mismatch repair protein HexB [Ensembl]. Histidine...	0.06	OrthoFinder
AKI49401	mutL, L2625_01501	DNA mismatch repair protein [Ensembl]. DNA mismatch...	0.08	OrthoFinder
CCL18232	mutL, BN171_2170019	DNA mismatch repair protein MutL [Ensembl]. MutL C...	0.04	OrthoFinder
EDJ91210	CGSHi22421_01789	DNA mismatch repair protein [Ensembl]. Histidine...	0.03	OrthoFinder

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	None	Extended
MF	GO:0003690	double-stranded DNA binding	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	Interproscan
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006281	DNA repair	None	Extended
BP	GO:0006298	mismatch repair	IEA	Interproscan
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006950	response to stress	None	Extended
BP	GO:0006974	cellular response to DNA damage stimulus	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0030983	mismatched DNA binding	IEA	Interproscan
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0033554	cellular response to stress	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051716	cellular response to stimulus	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0003723	RNA binding	IEP	Enrichment
MF	GO:0003824	catalytic activity	IEP	Enrichment
MF	GO:0003909	DNA ligase activity	IEP	Enrichment
MF	GO:0003911	DNA ligase (NAD+) activity	IEP	Enrichment
MF	GO:0004521	endoribonuclease activity	IEP	Enrichment
MF	GO:0004525	ribonuclease III activity	IEP	Enrichment
MF	GO:0004812	aminoacyl-tRNA ligase activity	IEP	Enrichment
MF	GO:0004813	alanine-tRNA ligase activity	IEP	Enrichment
MF	GO:0004814	arginine-tRNA ligase activity	IEP	Enrichment
MF	GO:0004826	phenylalanine-tRNA ligase activity	IEP	Enrichment
MF	GO:0005515	protein binding	IEP	Enrichment
MF	GO:0005525	GTP binding	IEP	Enrichment
CC	GO:0005694	chromosome	IEP	Enrichment
CC	GO:0005737	cytoplasm	IEP	Enrichment
BP	GO:0006396	RNA processing	IEP	Enrichment
BP	GO:0006399	tRNA metabolic process	IEP	Enrichment
BP	GO:0006418	tRNA aminoacylation for protein translation	IEP	Enrichment
BP	GO:0006419	alanyl-tRNA aminoacylation	IEP	Enrichment
BP	GO:0006420	arginyl-tRNA aminoacylation	IEP	Enrichment
BP	GO:0006432	phenylalanyl-tRNA aminoacylation	IEP	Enrichment
BP	GO:0006520	cellular amino acid metabolic process	IEP	Enrichment
BP	GO:0006605	protein targeting	IEP	Enrichment
BP	GO:0006612	protein targeting to membrane	IEP	Enrichment
BP	GO:0006613	cotranslational protein targeting to membrane	IEP	Enrichment
BP	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	IEP	Enrichment
BP	GO:0006886	intracellular protein transport	IEP	Enrichment
MF	GO:0008168	methyltransferase activity	IEP	Enrichment
MF	GO:0008173	RNA methyltransferase activity	IEP	Enrichment
MF	GO:0008175	tRNA methyltransferase activity	IEP	Enrichment
MF	GO:0008961	phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity	IEP	Enrichment
BP	GO:0016070	RNA metabolic process	IEP	Enrichment
MF	GO:0016426	tRNA (adenine) methyltransferase activity	IEP	Enrichment
MF	GO:0016429	tRNA (adenine-N1-)-methyltransferase activity	IEP	Enrichment
MF	GO:0016741	transferase activity, transferring one-carbon groups	IEP	Enrichment
MF	GO:0016787	hydrolase activity	IEP	Enrichment
MF	GO:0016874	ligase activity	IEP	Enrichment
MF	GO:0016875	ligase activity, forming carbon-oxygen bonds	IEP	Enrichment
MF	GO:0016886	ligase activity, forming phosphoric ester bonds	IEP	Enrichment
MF	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	IEP	Enrichment
MF	GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	IEP	Enrichment
MF	GO:0019001	guanyl nucleotide binding	IEP	Enrichment
MF	GO:0032296	double-stranded RNA-specific ribonuclease activity	IEP	Enrichment
MF	GO:0032561	guanyl ribonucleotide binding	IEP	Enrichment
BP	GO:0033365	protein localization to organelle	IEP	Enrichment
BP	GO:0034613	cellular protein localization	IEP	Enrichment
BP	GO:0034660	ncRNA metabolic process	IEP	Enrichment
BP	GO:0042157	lipoprotein metabolic process	IEP	Enrichment
BP	GO:0042158	lipoprotein biosynthetic process	IEP	Enrichment
BP	GO:0043038	amino acid activation	IEP	Enrichment
BP	GO:0043039	tRNA aminoacylation	IEP	Enrichment
BP	GO:0045047	protein targeting to ER	IEP	Enrichment
BP	GO:0046907	intracellular transport	IEP	Enrichment
BP	GO:0051641	cellular localization	IEP	Enrichment
BP	GO:0051649	establishment of localization in cell	IEP	Enrichment
BP	GO:0051668	localization within membrane	IEP	Enrichment
BP	GO:0070727	cellular macromolecule localization	IEP	Enrichment
BP	GO:0070972	protein localization to endoplasmic reticulum	IEP	Enrichment
BP	GO:0072594	establishment of protein localization to organelle	IEP	Enrichment
BP	GO:0072599	establishment of protein localization to endoplasmic reticulum	IEP	Enrichment
BP	GO:0072657	protein localization to membrane	IEP	Enrichment
BP	GO:0090150	establishment of protein localization to membrane	IEP	Enrichment
MF	GO:0140098	catalytic activity, acting on RNA	IEP	Enrichment
MF	GO:0140101	catalytic activity, acting on a tRNA	IEP	Enrichment

InterPro domains	Description	Start	Stop
IPR014790	MutL_C	483	625
IPR013507	DNA_mismatch_S5_2-like	209	325

External Links

No external refs found!

CPC34369 (mutL, ERS093114_00128)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation