CRP57553 (folD)


Aliases : folD

Description : Bifunctional protein FolD protein [Ensembl]. Tetrahydrofolate dehydrogenase/cyclohydrolase [Interproscan].


Gene families : OG_02_0000724 (OrthoFinder) Phylogenetic Tree(s): OG0000724_tree

Sequence : coding (download), protein (download)


Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.


Type Description Actions
Neighborhood HRR: CRP57553
Cluster HCCA: Cluster_61

Target Alias Description ECC score Gene Family Method Actions
AAC73631 folD, b0529 bifunctional 5,10-methylene-tetrahydrofolate... 0.09 OrthoFinder
AAL19496 STM0542, folD 5,10-methylene-tetrahydrofolate dehydrogenase [Ensembl].... 0.07 OrthoFinder
AEA93399 folD, OG1RF_10712 bifunctional methylenetetrahydrofolate... 0.03 OrthoFinder
AKI49356 folD, L2625_01453 methylenetetrahydrofolate... 0.03 OrthoFinder
AKP14964 folD, WX61_00901 Bifunctional protein FolD protein [Ensembl].... 0.04 OrthoFinder

Type GO Term Name Evidence Source
MF GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA Interproscan
BP GO:0055114 obsolete oxidation-reduction process IEA Interproscan
Type GO Term Name Evidence Source
MF GO:0000166 nucleotide binding IEP Enrichment
BP GO:0001522 pseudouridine synthesis IEP Enrichment
MF GO:0003676 nucleic acid binding IEP Enrichment
MF GO:0003723 RNA binding IEP Enrichment
MF GO:0003747 translation release factor activity IEP Enrichment
MF GO:0003864 3-methyl-2-oxobutanoate hydroxymethyltransferase activity IEP Enrichment
MF GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity IEP Enrichment
MF GO:0004424 imidazoleglycerol-phosphate dehydratase activity IEP Enrichment
MF GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity IEP Enrichment
MF GO:0004812 aminoacyl-tRNA ligase activity IEP Enrichment
MF GO:0004820 glycine-tRNA ligase activity IEP Enrichment
MF GO:0004832 valine-tRNA ligase activity IEP Enrichment
MF GO:0004853 uroporphyrinogen decarboxylase activity IEP Enrichment
MF GO:0005315 inorganic phosphate transmembrane transporter activity IEP Enrichment
MF GO:0005488 binding IEP Enrichment
MF GO:0005524 ATP binding IEP Enrichment
CC GO:0005737 cytoplasm IEP Enrichment
BP GO:0006082 organic acid metabolic process IEP Enrichment
BP GO:0006139 nucleobase-containing compound metabolic process IEP Enrichment
BP GO:0006188 IMP biosynthetic process IEP Enrichment
BP GO:0006399 tRNA metabolic process IEP Enrichment
BP GO:0006415 translational termination IEP Enrichment
BP GO:0006418 tRNA aminoacylation for protein translation IEP Enrichment
BP GO:0006426 glycyl-tRNA aminoacylation IEP Enrichment
BP GO:0006438 valyl-tRNA aminoacylation IEP Enrichment
BP GO:0006450 regulation of translational fidelity IEP Enrichment
BP GO:0006520 cellular amino acid metabolic process IEP Enrichment
BP GO:0006721 terpenoid metabolic process IEP Enrichment
BP GO:0006725 cellular aromatic compound metabolic process IEP Enrichment
BP GO:0006753 nucleoside phosphate metabolic process IEP Enrichment
BP GO:0006779 porphyrin-containing compound biosynthetic process IEP Enrichment
BP GO:0006793 phosphorus metabolic process IEP Enrichment
BP GO:0006796 phosphate-containing compound metabolic process IEP Enrichment
BP GO:0006807 nitrogen compound metabolic process IEP Enrichment
MF GO:0008079 translation termination factor activity IEP Enrichment
MF GO:0008135 translation factor activity, RNA binding IEP Enrichment
BP GO:0008150 biological_process IEP Enrichment
BP GO:0008152 metabolic process IEP Enrichment
BP GO:0008610 lipid biosynthetic process IEP Enrichment
MF GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity IEP Enrichment
MF GO:0008883 glutamyl-tRNA reductase activity IEP Enrichment
BP GO:0009058 biosynthetic process IEP Enrichment
BP GO:0009116 nucleoside metabolic process IEP Enrichment
BP GO:0009117 nucleotide metabolic process IEP Enrichment
BP GO:0009123 nucleoside monophosphate metabolic process IEP Enrichment
BP GO:0009124 nucleoside monophosphate biosynthetic process IEP Enrichment
BP GO:0009126 purine nucleoside monophosphate metabolic process IEP Enrichment
BP GO:0009127 purine nucleoside monophosphate biosynthetic process IEP Enrichment
BP GO:0009156 ribonucleoside monophosphate biosynthetic process IEP Enrichment
BP GO:0009161 ribonucleoside monophosphate metabolic process IEP Enrichment
BP GO:0009165 nucleotide biosynthetic process IEP Enrichment
BP GO:0009167 purine ribonucleoside monophosphate metabolic process IEP Enrichment
BP GO:0009168 purine ribonucleoside monophosphate biosynthetic process IEP Enrichment
CC GO:0009360 DNA polymerase III complex IEP Enrichment
BP GO:0009435 NAD biosynthetic process IEP Enrichment
BP GO:0009451 RNA modification IEP Enrichment
BP GO:0009890 negative regulation of biosynthetic process IEP Enrichment
MF GO:0009982 pseudouridine synthase activity IEP Enrichment
BP GO:0009987 cellular process IEP Enrichment
BP GO:0010558 negative regulation of macromolecule biosynthetic process IEP Enrichment
BP GO:0015939 pantothenate metabolic process IEP Enrichment
BP GO:0015940 pantothenate biosynthetic process IEP Enrichment
BP GO:0016070 RNA metabolic process IEP Enrichment
BP GO:0016114 terpenoid biosynthetic process IEP Enrichment
MF GO:0016740 transferase activity IEP Enrichment
MF GO:0016741 transferase activity, transferring one-carbon groups IEP Enrichment
MF GO:0016742 hydroxymethyl-, formyl- and related transferase activity IEP Enrichment
MF GO:0016744 transketolase or transaldolase activity IEP Enrichment
MF GO:0016817 hydrolase activity, acting on acid anhydrides IEP Enrichment
MF GO:0016829 lyase activity IEP Enrichment
MF GO:0016835 carbon-oxygen lyase activity IEP Enrichment
MF GO:0016836 hydro-lyase activity IEP Enrichment
MF GO:0016842 amidine-lyase activity IEP Enrichment
MF GO:0016866 intramolecular transferase activity IEP Enrichment
MF GO:0016874 ligase activity IEP Enrichment
MF GO:0016875 ligase activity, forming carbon-oxygen bonds IEP Enrichment
MF GO:0017076 purine nucleotide binding IEP Enrichment
BP GO:0018130 heterocycle biosynthetic process IEP Enrichment
BP GO:0019438 aromatic compound biosynthetic process IEP Enrichment
BP GO:0019637 organophosphate metabolic process IEP Enrichment
BP GO:0019752 carboxylic acid metabolic process IEP Enrichment
BP GO:0022411 cellular component disassembly IEP Enrichment
MF GO:0030554 adenyl nucleotide binding IEP Enrichment
BP GO:0031324 negative regulation of cellular metabolic process IEP Enrichment
BP GO:0031327 negative regulation of cellular biosynthetic process IEP Enrichment
MF GO:0032553 ribonucleotide binding IEP Enrichment
MF GO:0032555 purine ribonucleotide binding IEP Enrichment
MF GO:0032559 adenyl ribonucleotide binding IEP Enrichment
BP GO:0032984 protein-containing complex disassembly IEP Enrichment
BP GO:0033013 tetrapyrrole metabolic process IEP Enrichment
BP GO:0033014 tetrapyrrole biosynthetic process IEP Enrichment
BP GO:0034641 cellular nitrogen compound metabolic process IEP Enrichment
BP GO:0034660 ncRNA metabolic process IEP Enrichment
MF GO:0035596 methylthiotransferase activity IEP Enrichment
MF GO:0035639 purine ribonucleoside triphosphate binding IEP Enrichment
MF GO:0036094 small molecule binding IEP Enrichment
CC GO:0042575 DNA polymerase complex IEP Enrichment
BP GO:0043038 amino acid activation IEP Enrichment
BP GO:0043039 tRNA aminoacylation IEP Enrichment
MF GO:0043168 anion binding IEP Enrichment
BP GO:0043170 macromolecule metabolic process IEP Enrichment
BP GO:0043412 macromolecule modification IEP Enrichment
BP GO:0043436 oxoacid metabolic process IEP Enrichment
BP GO:0043624 cellular protein complex disassembly IEP Enrichment
BP GO:0043933 protein-containing complex subunit organization IEP Enrichment
BP GO:0044237 cellular metabolic process IEP Enrichment
BP GO:0044238 primary metabolic process IEP Enrichment
BP GO:0044249 cellular biosynthetic process IEP Enrichment
BP GO:0044271 cellular nitrogen compound biosynthetic process IEP Enrichment
BP GO:0044281 small molecule metabolic process IEP Enrichment
MF GO:0045182 translation regulator activity IEP Enrichment
BP GO:0045892 negative regulation of transcription, DNA-templated IEP Enrichment
BP GO:0045934 negative regulation of nucleobase-containing compound metabolic process IEP Enrichment
BP GO:0046040 IMP metabolic process IEP Enrichment
BP GO:0046483 heterocycle metabolic process IEP Enrichment
MF GO:0050497 alkylthioltransferase activity IEP Enrichment
BP GO:0051172 negative regulation of nitrogen compound metabolic process IEP Enrichment
BP GO:0051253 negative regulation of RNA metabolic process IEP Enrichment
BP GO:0055086 nucleobase-containing small molecule metabolic process IEP Enrichment
CC GO:0061695 transferase complex, transferring phosphorus-containing groups IEP Enrichment
BP GO:0071704 organic substance metabolic process IEP Enrichment
MF GO:0090079 translation regulator activity, nucleic acid binding IEP Enrichment
BP GO:0090304 nucleic acid metabolic process IEP Enrichment
BP GO:0090407 organophosphate biosynthetic process IEP Enrichment
MF GO:0097159 organic cyclic compound binding IEP Enrichment
MF GO:0097367 carbohydrate derivative binding IEP Enrichment
MF GO:0140098 catalytic activity, acting on RNA IEP Enrichment
MF GO:0140101 catalytic activity, acting on a tRNA IEP Enrichment
CC GO:0140535 intracellular protein-containing complex IEP Enrichment
BP GO:1901135 carbohydrate derivative metabolic process IEP Enrichment
MF GO:1901265 nucleoside phosphate binding IEP Enrichment
BP GO:1901293 nucleoside phosphate biosynthetic process IEP Enrichment
BP GO:1901360 organic cyclic compound metabolic process IEP Enrichment
BP GO:1901362 organic cyclic compound biosynthetic process IEP Enrichment
MF GO:1901363 heterocyclic compound binding IEP Enrichment
BP GO:1901564 organonitrogen compound metabolic process IEP Enrichment
BP GO:1901566 organonitrogen compound biosynthetic process IEP Enrichment
BP GO:1901576 organic substance biosynthetic process IEP Enrichment
BP GO:1901657 glycosyl compound metabolic process IEP Enrichment
BP GO:1902679 negative regulation of RNA biosynthetic process IEP Enrichment
BP GO:1903507 negative regulation of nucleic acid-templated transcription IEP Enrichment
CC GO:1990234 transferase complex IEP Enrichment
BP GO:2000113 negative regulation of cellular macromolecule biosynthetic process IEP Enrichment
InterPro domains Description Start Stop
IPR020631 THF_DH/CycHdrlase_NAD-bd_dom 124 281
IPR020630 THF_DH/CycHdrlase_cat_dom 5 121